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130407

Insulin Resistance in Pediatric Systemic Lupus Erythematosus and Rheumatoid Arthritis

Article

Last updated: 22 Jan 2023

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Tags

Clinical Research (Medical)

Abstract

Background: Childhood rheumatologic disorders are multisystem diseases characterized by inflammation, damage, and/or pain of the joints, and connective tissues. Aim: This study aimed to detect the presence of insulin resistance (IR) in pediatric patients with systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) which can lead to the development of diabetes mellitus. Subjects and Methods: This case-control study was performed on 60 SLE, 60 RA patients, and 60 healthy subjects as a control group. All subjects were subjected to detailed history taking, physical examination, and laboratory investigations including determination of fasting blood glucose (FBG), total cholesterol, triglyceride (TG), HDL, LDL, and fasting insulin. Homeostatic model assessment of insulin resistance (HOMA IR) was calculated. Results: There was no significant difference in the age, and FBG in the three studied groups but there was a significant difference as regard platelets counts, hemoglobin, ESR, CRP, TG, HDL, fasting insulin levels, and HOMA IR. There is no significant difference between the SLE, and RA in disease duration, ESR, CRP, HDL, LDL, triglyceride, cholesterol, fasting blood glucose, fasting insulin levels, and HOMA IR. There were significant positive correlations between HOMA IR with patients' BMI, ESR, CRP, TG, FBG, and fasting insulin levels in both SLE and RA groups. Conclusions: SLE, and RA patients had a higher insulin resistance than age-matched healthy controls which can lead to the development of type 2 diabetes mellitus. HOMA IR had positive correlations with BMI, TG, FBG, and fasting insulin levels in both SLE and RA groups.
 

DOI

10.21608/scumj.2020.130407

Keywords

Insulin Resistance, Cholesterol, triglyceride

Authors

First Name

Mohamed

Last Name

Talat

MiddleName

A

Affiliation

Department of Pediatrics, Zagazig University, Egypt

Email

abo.talat@yahoo.com

City

-

Orcid

0000-0002-1548-5720

First Name

Hossam

Last Name

Kamal

MiddleName

-

Affiliation

Department of Pediatrics, Zagazig University, Egypt

Email

hosamyousef90@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdelsalam

MiddleName

M

Affiliation

Department of Pediatrics, Zagazig University, Egypt

Email

mohammedabdelsalem732@yahoo.com

City

-

Orcid

-

First Name

Hesham

Last Name

Ramadan

MiddleName

S

Affiliation

Department of Pediatrics, Zagazig University, Egypt

Email

hesham_s3d@yahoo.com

City

-

Orcid

-

First Name

Hanaa

Last Name

El Said

MiddleName

H

Affiliation

Department of Clinical Pathology, Zagazig University, Egypt

Email

hanaahosny52@yahoo.com

City

-

Orcid

-

First Name

Rabab

Last Name

Saleh

MiddleName

M

Affiliation

Department of Pediatrics, Zagazig University, Egypt

Email

rababonline1@yahoo.com

City

-

Orcid

0000-0001-9146-2494

Volume

23

Article Issue

2

Related Issue

18442

Issue Date

2020-10-01

Receive Date

2020-12-17

Publish Date

2020-10-01

Page Start

192

Page End

200

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 23_Issue 2_Pages 192-200.pdf

PDF . 381.1kB

Link

https://scumj.journals.ekb.eg/article_130407.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=130407

Order

10

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023