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127158

Predictors of Functional Outcome After Treatment of Acute Ischemic Stroke

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Last updated: 04 Jan 2025

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Clinical Research (Medical)

Abstract

Background: Acute ischemic stroke (AIS) is a common condition with significant consequences. Advances in treatment modified outcome and prognosis. Aim: The present study aimed to discuss the predictors of functional outcome of AIS after the first three months. Patients and Methods: All the studied 131 patients had careful history taking, thorough clinical examination, and non-contrast brain CT scans. The initial severity of the stroke and evolution after thrombolysis was evaluated using the National Instituted of Health Stroke Scale (NIHSS). Patients were treated with low molecular weight heparin (LMWH) or rt-PA. Functional status at three months was evaluated using the modified Rankin Scale. Results: The present study included 131 patients with AIS. Favorable functional outcome was achieved in 52 patients (39.7 %) while the remainder 79 patients had a poor outcome. Using logistic regression analysis, significant predictors of poor outcome on univariate analysis included age ≥ 60 years (OR:3.2, CI: 1.3-7.9,p=0.014), presence of atheromatous plaques (OR: 16.8, CI: 4.8-58.3, p < 0.001), late initiation of treatment (OR: 10.6, CI: 3.4-32.1,p < 0.001) and persistent occlusion (OR: 7.8, CI: 3.2-18.8, p < 0.001). However, on multivariate analysis, variable predictive of poor outcome included age ≥ 60 years (OR: 32.5, CI: 5.4-196.5, p < 0.001), presence of atheromatous plaques (OR: 9.4, CI: 1.7-51.2, p= 0.01), late initiation of treatment (OR: 10.0, CI: 1.5-67.1,p= 0.018) and persistent occlusion (OR:25.7, CI: 6.9-95.8,p < 0.001). Conclusions: Independent predictors of poor outcome in AIS patients include age ≥ 60 years, presence of atheromatous plaques, late initiation of treatment, and persistent occlusion.
 

DOI

10.21608/scumj.2020.127158

Keywords

Acute ischemic stroke, Recombinant tissue plasminogen activator, functional outcome

Authors

First Name

Emad

Last Name

Abdel-Monem

MiddleName

F.

Affiliation

Department of Neurology, Al-Azhar University Faculty of Medicine, Al-Hussein University Hospital, Cairo, Egypt

Email

emad.shahien25@gmail.com

City

-

Orcid

-

First Name

Fathy

Last Name

Afifi

MiddleName

M.

Affiliation

Department of Neurology, Al-Azhar University Faculty of Medicine, Al-Hussein University Hospital, Cairo, Egypt

Email

fathi_288@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Essmat

MiddleName

-

Affiliation

Department of Neurology, Al-Azhar University Faculty of Medicine, Al-Hussein University Hospital, Cairo, Egypt

Email

ahmadesmat81@yahoo.com

City

-

Orcid

-

Volume

23

Article Issue

2

Related Issue

18442

Issue Date

2020-10-01

Receive Date

2020-12-03

Publish Date

2020-10-01

Page Start

176

Page End

181

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 23_Issue 2_Pages 176-181.pdf

PDF . 262.3kB

Link

https://scumj.journals.ekb.eg/article_127158.html

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https://scumj.journals.ekb.eg/service?article_code=127158

Order

8

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Predictors of Functional Outcome After Treatment of Acute Ischemic Stroke

Details

Type

Article

Created At

22 Jan 2023