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123149

Chronic Pesticides Exposure and Thyroid Functions among Farmers in Almnaif District - Ismailia Governorate, Egypt

Article

Last updated: 22 Jan 2023

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-

Tags

Clinical Research (Medical)

Abstract

Background: There is growing evidence that environmental exposure, specifically to pesticides, a potential risk factor for endocrine system malfunction. Aim: The study aims at contributing to improve the wellbeing and productivity of farmers through a better understanding of chronic pesticides exposure and its effect on thyroid functions. Patients and Methods: An analytical cross-sectional study was conducted on 43 farmers with active involvement in the preparation, storage, and spraying of the pesticides and 43 participants not occupationally exposed to pesticides. All participants were interviewed using a structured questionnaire including sociodemographic characteristics, pesticides exposure characteristics, and safety measures. The blood levels of plasma cholinesterase enzyme, and thyroid hormones (TSH, T4) were measured for all participants. Results: The mean duration of exposure was 20.60±11.06 years. The pesticide-exposed farmers had a statistically significant lower level of plasma cholinesterase enzyme (3969.93±1841.84 U/L) compared to the control group (4879.29±1950.08 U/L) (p < 0.05). Moreover, thyroid-stimulating hormone level (TSH) was significantly higher in exposed farmers (median=1.39µIU/ml) compared to controls (median=0.91µIU/ml) (p < /em>=0.032). While the exposed group had a lower level of thyroxine hormone (T4) (6.91±1.91 µg/dl) compared to the control group (7.79±2.10µg/dl), with a statistically significant difference between the two groups (p < /em>=0.045). Conclusion: Exposure to organophosphates and carbamates affects thyroid function in the form of a decrease in the circulating level of thyroxine hormone, increase in the TSH level.
 

DOI

10.21608/scumj.2020.123149

Keywords

Pesticides, farmers, Thyroid Stimulating Hormone (TSH), thyroxine hormone (T4)

Authors

First Name

Bassma

Last Name

Ibrahim

MiddleName

A

Affiliation

Department of Industrial Medicine and Occupational Health, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Shaimaa

Last Name

Amer

MiddleName

A

Affiliation

Department of Industrial Medicine and Occupational Health, Faculty of Medicine, Suez Canal University, Egypt

Email

shaymaamoussa@yahoo.com

City

-

Orcid

-

First Name

Soha

Last Name

Younis

MiddleName

E

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

sohayounes@gmail.com

City

-

Orcid

-

First Name

Mostafa

Last Name

Kofi

MiddleName

F

Affiliation

Department of Industrial Medicine and Occupational Health, Faculty of Medicine, Suez Canal University, Egypt

Email

moustafafouad@yahoo.com

City

-

Orcid

-

First Name

Amani

Last Name

Abdel-Halim

MiddleName

W

Affiliation

Department of Industrial Medicine and Occupational Health, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

23

Article Issue

2

Related Issue

18442

Issue Date

2020-10-01

Receive Date

2020-11-14

Publish Date

2020-10-01

Page Start

117

Page End

128

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 23_Issue 2_Pages 117-128.pdf

PDF . 375.0kB

Link

https://scumj.journals.ekb.eg/article_123149.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=123149

Order

2

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023