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118477

Chicory vs. Zinc: The Protective Role in Alcohol-Induced Acute Liver Injury

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Last updated: 04 Jan 2025

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Abstract

Background: Ethanol is a natural product of plant fermentation. It is used as an antibacterial substance, food addictive, and alcoholic beverages. Excessive consumption of ethanol can lead to degenerative effects in many organs. Aim: T0 compare between the effect of zinc and chicory (Cichorium intybus) as protective agents in alcohol-induced liver damage. Material and Methods: Forty male albino rats (150-200g) were divided into four groups (10 rats each):group1(control group), group 2:rats were treated with 1ml /kg/BW of 70% ethanol orally by stomach gavage, group 3: rats were treated with 1ml/kg/BW of 70% ethanol and 5 mg/kg/day of zinc sulfate orally by stomach gavage for and, group 4: rats treated with 1ml/kg/BW of 70% ethanol orally by stomach gavage and chicory within the diet for consecutive 5 days. The animals will be anesthetized and subjected to intracardiac normal saline 0.9% NaCl. Liver specimens were extracted for further processing. Results: vasodilatation in portal vein congestion of the hepatic sinusoids and degenerative changes of the hepatocytes. In group III, there was no inflammatory signs, but more damage was detected in hepatic parenchyma. Chicory treated samples had no signs of inflammation. hepatic parenchyma had a mild degree of degeneration. Conclusion: excessive consumption of alcohol lead to acute liver damage and both zinc and chicory had a protective role in decreasing signs of liver damage, but chicory was more protective than zinc in the preservation of liver tissue against damage. 

DOI

10.21608/scumj.2020.118477

Keywords

ethanol, Alcohol toxicity

Authors

First Name

Ali

Last Name

Abdel Rahmman

MiddleName

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Affiliation

Department of Gastroenterology, Faculty of Medicine, South Valley University

Email

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City

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Orcid

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First Name

Soha

Last Name

Soliman

MiddleName

-

Affiliation

Department of Histology, Faculty of Medicine, South Valley University

Email

-

City

-

Orcid

-

First Name

Maha

Last Name

Fahmy

MiddleName

A

Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, South Valley University

Email

mahaabdelbaki6@gmail.com

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-

Orcid

-

Volume

23

Article Issue

1

Related Issue

17184

Issue Date

2020-03-01

Receive Date

2020-10-13

Publish Date

2020-03-01

Page Start

51

Page End

61

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 23_Issue 1_Pages 51-61.pdf

PDF . 2.0MB

Link

https://scumj.journals.ekb.eg/article_118477.html

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https://scumj.journals.ekb.eg/service?article_code=118477

Order

6

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Chicory vs. Zinc: The Protective Role in Alcohol-Induced Acute Liver Injury

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Article

Created At

22 Jan 2023