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110507

Serum Immunoglobulins in Children with Vitamin D Resistant Rickets

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Last updated: 22 Jan 2023

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Abstract

Background: Vitamin D plays an immunoregulatory role in both the innate and adaptive immune systems. Rickets is a disorder that can develop due to a lack of vitamin D, calcium, or phosphate. Aim: The aim of this study was to assess serum immunoglobulins as one of the aspects of humoral immunity in children with vitamin D resistant rickets. Subjects and Methods: This case-control study was performed on 60 patients divided into Group (A):30 cases with vitamin D resistant rickets patients who were presented with rachitic manifestation who didn't respond to therapeutic doses of the vitamin. Group (B):30 cases with untreated classic vitamin D deficiency rickets. Group (C): 30 healthy subjects as a control group. All subjects were subjected to detailed history taking including age, sex, weight, dietary history, medication history, and physical examination including vital signs, body weight, and head circumference. Laboratory investigations that included calcium, phosphorus, alkaline phosphatase, electrolytes, ESR, urine analysis, parathyroid hormone, vitamin D, and Immunoglobulin assay. Results: There is a significant decrease of IgA in vitamin D deficiency rickets and vitamin D resistant rickets than in controls (3.74 ± .867, 3.13 ± 1.72, 5.01 ± 1.61, respectively with P =0.012).There is a significant decrease of IgG in vitamin D deficiency rickets and a significant increase in vitamin D resistant rickets than in controls (523.5 ± 136.3, 751.25 ±163.5, 692.0 ± 186.4, respectively with P =0.009). There is no significant difference in IgM in the three studied groups. Conclusion: Patients with vitamin D deficiency have significantly lower IgG levels, while vitamin D resistant patients have significantly higher IgG levels. Whereas, both groups have lower IgA and normal IgM levels.

DOI

10.21608/scumj.2019.110507

Keywords

25-Hydroxyvitamin D, calcium, phosphorus, PTH, vitamin D receptor gene

Authors

First Name

Ezzat

Last Name

Amin

MiddleName

-

Affiliation

Department of Pediatrics's, Zagazig University, Egypt

Email

dr_ezat_kamel@yahoo.com

City

-

Orcid

0000-0002-2329-6073

First Name

Hossam

Last Name

Kamal

MiddleName

-

Affiliation

Department of Pediatrics's, Zagazig University, Egypt

Email

hosamyousef90@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Gab-Allah

MiddleName

-

Affiliation

Department of Clinical Pathology, Tarablus University Hospital, Libya

Email

agaballaa2011@yahoo.com

City

-

Orcid

-

First Name

Seham

Last Name

Alzarrouq

MiddleName

-

Affiliation

Department of Pediatrics's, Tarablus University Hospital, Libya

Email

somaiyad83@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Talat

MiddleName

A

Affiliation

Department of Pediatrics's, Zagazig University, Egypt

Email

abo.talat@yahoo.com

City

-

Orcid

0000-0002-1548-5720

Volume

22

Article Issue

2

Related Issue

14304

Issue Date

2019-10-01

Receive Date

2020-09-01

Publish Date

2019-10-01

Page Start

157

Page End

163

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 22_Issue 2_Pages 157-163.pdf

PDF . 319.3kB

Link

https://scumj.journals.ekb.eg/article_110507.html

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https://scumj.journals.ekb.eg/service?article_code=110507

Order

7

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023