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97996

Circulating sTWEAK Levels and Diabetic Nephropathy in Type 2 Diabetic Patients

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Last updated: 04 Jan 2025

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Abstract

Background: Diabetic nephropathy (DN) is one of the major complications of diabetes mellitus (DM) that leads to end stage renal disease (ESRD). There is a need for novel biomarkers for early detection and follow up of patients with DN. TNF-like weak inducer of apoptosis (TWEAK) is thought to be involved in the progression of DN through the fibroblast growth factor inducible-14 (Fn14) pathway. Accordingly, blood soluble form of TWEAK (sTWEAK) could be a marker for the progression of and degree of DN. Aim: To assess the relationship between circulating sTWEAK levels and DN in type 2 diabetic patients as it could be a good potential biomarker for detection and follow up of DN patients. Patients and Methods:Sixty type 2 DM patients were selected to be 30 with DN and 30 without DN. DN patients were further divided into 20 microalbuminuric and 10 macro-albuminuric patients. Twenty normal subjects served as a control group. Patients were tested for serum creatinine, lipid prolife, glycated hemoglobin, urinary albumin creatinine ratio (ACR), estimated glomerular filtration rate (eGFR) and serum sTWEAK. Results: Serum sTWEAK was found to change significantly with the level of albuminuria with its lowest level in the macro-albuminuric group (P <0.0001). There was a significant positive correlation between serum sTWEAK and eGFR (r =0.315, p- value =0.014). Furthermore, sTWEAK showed good diagnostic value for detection of macro-albuminuria, with 90% sensitivity and 70% Specificity. Conclusion: Serum sTWEAK could be a good biomarker for detection and follow up of DN. 

DOI

10.21608/scumj.2019.97996

Keywords

DN, sTWEAK, ACR, eGFR

Authors

First Name

Sara

Last Name

Habash

MiddleName

A

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdalla

MiddleName

O

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

mosamaali@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Fekry

Last Name

Eskandar

MiddleName

G

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Nashwa

Last Name

Hassan

MiddleName

R

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

22

Article Issue

2

Related Issue

14304

Issue Date

2019-10-01

Receive Date

2020-06-25

Publish Date

2019-10-01

Page Start

146

Page End

156

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 22_Issue 2_Pages 146-156.pdf

PDF . 390.0kB

Link

https://scumj.journals.ekb.eg/article_97996.html

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https://scumj.journals.ekb.eg/service?article_code=97996

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6

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Circulating sTWEAK Levels and Diabetic Nephropathy in Type 2 Diabetic Patients

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Type

Article

Created At

22 Jan 2023