Beta
ManageSearchChatDiscover
94977

Assessment of the Platelet Adenosine Diphosphate Receptor (ADP Receptor p2y12) Polymorphism in Coronary Heart Diseases Patients in Ismailia

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Cardiovascular diseases are the leading cause of death in developed countries. In Egypt mortality rates from coronary heart disease are one of the highest worldwide, also coronary heart diseases will be the leading cause of death in developing countries by the year 2020. P2Y12 ADP receptor gene polymorphism is now considered one important implication factor in atherothrombosis and coronary heart diseases. Aim: To assess the correlation between the platelet Adenosine Diphosphate receptor (P2Y12) polymorphism and coronary heart disease patients in Ismailia. Subject and Methods: An analytical case-control study; conducted on 100 volunteers divided into 2 groups; 50 for study (patient) group and 50 for the control group at Ismailia Hospitals' Cardiology premises (clinics & inpatient department) to assess the correlation between the platelet ADP receptor (P2Y12) polymorphism and coronary heart diseases in Ismailia. The patients were subjected to an Interview Questionnaire, clinical examination, and Laboratory Investigations and testing for P2Y12 gene polymorphism. Results: In the study group, 42% of patients were hypertensive, 48% were diabetics, 60% were dyslipidemic and 66% were smokers. In the control group individuals, 26% were hypertensive, 20% were diabetics, 12% were dyslipidemic and 24% were smokers. DNA extraction and examination for P2Y12 gene polymorphism were negative in all participants. Conclusion: Our study revealed that there is no correlation between the platelet ADP receptor (P2Y12) gene polymorphism and coronary heart diseases in Ismailia.
Keywords: Ischemic heart disease, Thrombophilia, Platelet glycoproteins, Atherothrombosis

DOI

10.21608/scumj.2019.94977

Authors

First Name

Ahmed

Last Name

Mohamed

MiddleName

A

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University.

Email

dr_ahmed_ali777@yahoo.com

City

-

Orcid

-

First Name

Alaa Eldin

Last Name

Abdelhamid

MiddleName

S

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University.

Email

-

City

-

Orcid

-

First Name

Hesham

Last Name

Ibrahim

MiddleName

H

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University.

Email

-

City

-

Orcid

-

First Name

Amany

Last Name

Hassan

MiddleName

M

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University.

Email

amanyemansara@yahoo.com

City

-

Orcid

-

Volume

22

Article Issue

2

Related Issue

14304

Issue Date

2019-10-01

Receive Date

2020-06-11

Publish Date

2019-10-01

Page Start

131

Page End

137

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 22_Issue 2_Pages 131-137.pdf

PDF . 256.9kB

Link

https://scumj.journals.ekb.eg/article_94977.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=94977

Order

4

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of the Platelet Adenosine Diphosphate Receptor (ADP Receptor p2y12) Polymorphism in Coronary Heart Diseases Patients in Ismailia

Details

Type

Article

Created At

22 Jan 2023