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94976

Urinary Monocyte Chemoattractant Protein -1 as A Diagnostic Marker of Lupus Nephritis

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Last updated: 22 Jan 2023

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Abstract

Background: Lupus nephritis accounts for significant morbidity and mortality in patients with systemic lupus erythematosus (SLE). Many biomarkers for renal involvement in SLE have been suggested in Egyptian patients; one of them is Monocyte chemoattractant protein-1 (MCP-1) which is one of the key chemokines that have chemotactic effect for monocytes and macrophages to sites of inflammation and may share in the pathogenesis of lupus nephritis (LN). Aim: The study aimed at assessing the role of MCP-1 in the early diagnosis of lupus nephritis and to explore any correlation its levels with disease activity and renal status. Subjects and Methods: The study was done as a case-control study where 60 SLE patients with lupus nephritis (30 patients with active LN and 30 patients with inactive LN) in addition to 30 healthy volunteers as control group were enrolled in the study and MCP-1 levels was determined using ELISA technique. Results: Urinary MCP-1 levels in SLE studied patients' groups were significantly higher than their level in the control group (p = 0.0001) and it was significantly higher in active LN than in non-active LN subgroups (P-value =0.0001). Conclusion: Urinary MCP-1 can be used as a marker for LN activity.
Keywords: SLE, Lupus nephritis, MCP-1

DOI

10.21608/scumj.2019.94976

Authors

First Name

Gamal

Last Name

Tawfik

MiddleName

A

Affiliation

Department of Internal Medicine, Nephrology Unit, Suez Canal University, Faculty of Medicine, Egypt

Email

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City

-

Orcid

-

First Name

Eman

Last Name

Ghareeb

MiddleName

A

Affiliation

Department of Internal Medicine, Nephrology Unit, Suez Canal University, Faculty of Medicine, Egypt

Email

emananwar26@yahoo.com

City

-

Orcid

-

First Name

Waleed

Last Name

Abd El-Waheed

MiddleName

O

Affiliation

Department of Internal Medicine, Nephrology Unit, Suez Canal University, Faculty of Medicine, Egypt

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Keshawy

MiddleName

M

Affiliation

Department of Internal Medicine, Nephrology Unit, Suez Canal University, Faculty of Medicine, Egypt

Email

-

City

-

Orcid

-

First Name

Heba

Last Name

Zaki

MiddleName

M

Affiliation

Department of Internal Medicine, Nephrology Unit, Suez Canal University, Faculty of Medicine, Egypt

Email

-

City

-

Orcid

-

Volume

22

Article Issue

2

Related Issue

14304

Issue Date

2019-10-01

Receive Date

2020-06-11

Publish Date

2019-10-01

Page Start

122

Page End

130

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 22_Issue 2_Pages 122-130.pdf

PDF . 395.6kB

Link

https://scumj.journals.ekb.eg/article_94976.html

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https://scumj.journals.ekb.eg/service?article_code=94976

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023