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94803

Impact of Serum Interleukin 6 among Helicobacter Pylori-Positive Adult Patients in Relation to upper gastrointestinal endoscopy findings

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Last updated: 04 Jan 2025

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Abstract

Background: Helicobacter pylori (H. pylori) is one of the most common chronic bacterial infections in humans and has a major etiologic role for several gastroduodenal diseases. Interleukin-6 (IL-6) is a multifunctional cytokine and H. Pylori may stimulate its production. Aim: To assess the serum level of IL-6 in H. pylori-infected patients and to study its relation to gastric endoscopy findings. Subjects and Patients and Methods: Eighty-four participants were enrolled; 42 patients with positive H. pylori (patient group “B"), and 42 age and gender-matched subjects with negative H. pylori (control group “A"). Out of 42 patients in group B, 21 patients were subjected to upper gastrointestinal endoscopy due to persistent gastric upset. The serum concentration of IL-6 was measured in all subjects by ELISA. Results: serum IL-6 was significantly higher in patients' group compared to control group (4.3 ± 0.7 vs 1.5 ± 0.3 pg/ml, p <0.05). The prevalence of IL-6 in infected patients with H. Pylori was 92%, with the highest levels in those with gastric ulcers. Conclusion: H. Pylori infection is associated with high serum levels of IL-6 especially in those with gastric ulcers.
Keywords: Helicobacter pylori; interleukin 6

DOI

10.21608/scumj.2019.94803

Authors

First Name

Seham

Last Name

Omar

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

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City

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Orcid

-

First Name

Mohamed

Last Name

Hassan

MiddleName

F

Affiliation

Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University,Egypt.

Email

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City

-

Orcid

-

First Name

Basma

Last Name

Hasan

MiddleName

B

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Port Said University, Egypt

Email

basmabdr@yahoo.com

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-

Orcid

-

Volume

22

Article Issue

2

Related Issue

14304

Issue Date

2019-10-01

Receive Date

2020-06-10

Publish Date

2019-10-01

Page Start

117

Page End

121

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 22_Issue 2_Pages 117-121.pdf

PDF . 225.3kB

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https://scumj.journals.ekb.eg/article_94803.html

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https://scumj.journals.ekb.eg/service?article_code=94803

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2

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Impact of Serum Interleukin 6 among Helicobacter Pylori-Positive Adult Patients in Relation to upper gastrointestinal endoscopy findings

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Article

Created At

22 Jan 2023