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57481

Expression of Syndecan-1 on Neutrophils in Patients with Type 2 Diabetes Mellitus

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Last updated: 22 Jan 2023

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Abstract

Background: Type 2 diabetes is a manifestation of an ongoing low-grade inflammation. In diabetes, impairment of neutrophil adhesion to the endothelium and migration to the site of inflammation were detected, which were associated closely with adhesion molecules expressed on neutrophils and endothelial cells. Patients and Methods: To determine the expression of syndecan-1 on the neutrophils in diabetic patients, 80 patients with type 2 diabetes mellitus were recruited, in addition to 40 healthy individuals with no history of glucose metabolism disorders as control group. Expression of syndecan-1 was determined using flow-cytometry, and the correlations between syndecan-1 expression and clinical characteristics were analyzed. Results: The percentage of neutrophils expressing syndecan-1 was found to be higher in diabetic patients than among the healthy control individuals. In addition, a statistically significant association was found between the percentage of syndecan-1 positive neutrophils and body mass index. A multiple regression analysis found that body mass index is a significant predictor of neutrophils expressing syndecan-1 in type 2 diabetes mellitus patients. Conclusion: Surface syndecan-1 on neutrophils is significantly enhanced in subjects with type 2 DM. It is also positively correlated with BMI.
 

DOI

10.21608/scumj.2011.57481

Keywords

Syndecan-1, Diabetes mellitus, Neutrophils

Authors

First Name

Mohamed

Last Name

El-Shabrawi

MiddleName

M

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Suez Canal University, Egypt

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City

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Orcid

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First Name

Nervana

Last Name

Bayoumy

MiddleName

MK

Affiliation

Department of Physiology, College of Medicine, King Saud University, KSA

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City

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Orcid

-

First Name

Hamdi

Last Name

Hassan

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

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Orcid

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Volume

14

Article Issue

1

Related Issue

7461

Issue Date

2011-03-01

Receive Date

2019-11-07

Publish Date

2011-03-01

Page Start

55

Page End

60

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 14_Issue 1_Pages 55-60.pdf

PDF . 471.3kB

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https://scumj.journals.ekb.eg/article_57481.html

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https://scumj.journals.ekb.eg/service?article_code=57481

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9

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023