Background: Subjects with diabetes have increased cardiovascular disease (CVD) risk compared to those without diabetes. Addressing CVD risk in diabetes remains important due to increasing diabetes prevalence worldwide and in Egypt in particular. Aim: Assessment of major risk factors, and mean global risk score to CVD in type 2 diabetic patients. Material and methods: This is a case control study carried on type 2 diabetic patients in Suez Canal University Hospital, Ismailia, Egypt. Two-hundred and sixty-four patients with type II diabetes, and a matched group of 268 non-diabetic subjects took part in the study. Clinical examination and biochemical analysis were collected. To assess the mean global cardiovascular risk scoring in type 2 diabetic patients a Framingham heart study was used. Results: The mean total risk among type 2 diabetic patients was significantly higher than the matched control group. Moreover, the mean total risk among females in the diabetic patients was higher than that among male patients. Whereas in control group, the total mean risk in males was significantly higher than in females. The major risk factors in diabetic patients including body mass index, blood pressure, postprandial blood sugar and hemoglobin, total cholesterol and triglyceride were significantly higher than in the control group. Conclusion: The study highlighted the cardiovascular risk in type 2 diabetic patients in Egypt. These data emphasize the importance of treating cardiovascular risk factors in diabetic patients more aggressively in order to prevent CVD events. Furthermore, health care providers must increase the awareness in diabetic patients to adopt better life style.