ManageChatDiscover
57470

Evaluation of Liver Functions in Beta-thalassemic Patients in Ismailia

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background and objective: Regular packed RBCs transfusion puts Beta-thalassemia major patients at a high risk of developing hepatic iron overload and hepatitis C viral infection. Aim: The aim of this study was to evaluate liver functions in thalassemic patients in Ismailia. A descriptive cross sectional study was carried out in the outpatient pediatric hematological clinic of Suez Canal University hospital. Material and Methods: A sample of 25 Egyptian transfusion dependant β-thalassemia major children was studied. Individual patients underwent full history undertaking, clinical examination and a panel of laboratory tests including hemoglobin level, alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum ferritin, hepatitis B surface antigen (HBs Ag) and hepatitis C virus antibody (HCV Ab). Results: Both ALT and AST means were elevated being 62.32 IU/L and 70.76 IU/L respectively. 32% of the studied patients were HCV Ab positive while no one was HBs Ag positive. A highly significant correlation between ALT and AST was found. There was a statistically significant relationship between serum ferritin and HCV Ab status. Conclusion: These findings suggest that both HCV and iron overload are the main causes of abnormal liver function in patients with thalassemia. The treatment of both problems if coexisting in patients with thalassemia is required to prevent progression to chronic liver diseases.  

DOI

10.21608/scumj.2011.57470

Keywords

hepatitis C, aminotransferase, transfusion, iron overload

Authors

First Name

Marwa

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Atef

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Alaa

Last Name

Zeitoun

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Hala

Last Name

El-Hagrasi

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Fadia

Last Name

Attia

MiddleName

M

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

14

Article Issue

1

Related Issue

7461

Issue Date

2011-03-01

Receive Date

2019-11-07

Publish Date

2011-03-01

Page Start

16

Page End

21

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 14_Issue 1_Pages 16-21.pdf

PDF . 170.8kB

Link

https://scumj.journals.ekb.eg/article_57470.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=57470

Order

4

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Evaluation of Liver Functions in Beta-thalassemic Patients in Ismailia

Details

Type

Article

Created At

22 Jan 2023