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56014

Effect of Alfacalcidol on Anemia in Renal Failure Patients

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Last updated: 04 Jan 2025

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Abstract

Background: Anemia is a major feature of chronic kidney disease (CKD). Additionally, secondary hyperparathyroidism (SHPT) has been associated with anemia in uremic patients. Administration of active vitamin D metabolites like alfacalcidol is established for PTH suppression and may also play a role in hematopoiesis. Aim:To investigate the effect of alfacalcidol on anemia and SHPT with end stage renal failure patients underwent hemodialysis. Subjects and Methods: In the present study 17 anemic patients over 15years, with serum level of PTH greater than 500pg/ml. The study was carried out by means of data collection and analysis of serum parathyroid hormone (PTH) and hemoglobin (Hb) levels in these patients. Results: Low serum PTH levels were detected in uremic patients treated with alfacalcidol. Also, in these patients, Hb levels increased. Serum PTH and Hb levels were inversely correlated. Conclusions: High-dose alfacalcidol can decrease serum PTH levels and elevate Hb level in uremic patients showing considerable resistance to Epoetin.    

DOI

10.21608/scumj.2011.56014

Keywords

Anemia, PTH, alfacalcidol, ESRD, uremic patients, SHPT

Authors

First Name

Dalal

Last Name

El-Ellisy

MiddleName

-

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Egypt.

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Orcid

-

First Name

Mohamed

Last Name

Ewais

MiddleName

M

Affiliation

Department of Pharmacology & Toxicology, Faculty of Medicine, Suez Canal University, Egypt.

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-

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-

Orcid

-

First Name

El-Sayed

Last Name

El-Awady

MiddleName

E

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Gamal

Last Name

Tawfik

MiddleName

A

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

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-

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Volume

14

Article Issue

1

Related Issue

7461

Issue Date

2011-03-01

Receive Date

2019-10-30

Publish Date

2011-03-01

Page Start

11

Page End

15

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 14_Issue 1_Pages 11-15.pdf

PDF . 121.8kB

Link

https://scumj.journals.ekb.eg/article_56014.html

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https://scumj.journals.ekb.eg/service?article_code=56014

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Effect of Alfacalcidol on Anemia in Renal Failure Patients

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Article

Created At

22 Jan 2023