The practice of medicine is becoming increasingly more complex. Physicians and other healthcare providers face increasing administrative and legal challenges. Malpractice Claim puts physician's finances, reputation, professional advancement, personal relationships and health at risk. In Egypt, medical malpractice problem has been magnified during the last few years. The roles and position of the medico-legal expert in the medical malpractice cases becomes more complex at the same time with overcoming the national barriers, situation which imposes the adjustment of the juridical environment to such extremely multifaceted situations. In the modern era, along with development of individual rights, it becomes more and more obvious that the responsibility level of the patient should not be undervalued in connection with the failure of the therapeutically act . Therefore medico-legal expertise involving technical difficulties must be standardized according to the last generation or even to experimental surgical techniques cases. Good medical practice and a good physician-patient relationship are still the best ways to minimize lawsuits and their repercussions.