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54794

Antenatal Dexamethasone Prior to Term Elective Caesarean Section and Incidence of Neonatal Respiratory Morbidity: A Randomized Trial

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Last updated: 22 Jan 2023

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Abstract

Background: Elective caesarean section is a risk factor for the development of neonatal respiratory complications, resulted in increased admission to neonatal special care units. Aim: To assess the effect of prophylactic corticosteroids administration before elective CS at term in reducing neonatal respiratory morbidity and admission to neonatal special care units. Subjects and Methods: This randomized trial has been conducted among women subjected to term elective CS at Obstetrics and Gynecology Department of Suez Canal University Hospitals. Women who were eligible for the study (n=226) were divided into two groups (study group and control group). At 37 weeks gestation, they received two intramuscular doses of 12mg dexamethasone, while the control group given the usual care without steroids. We examined adverse neonatal respiratory outcomes (Respiratory Distress Syndrome and Transient Tachypnea of the Newborn) and rates of neonatal care unit's admissions in both groups. Results: Neonates in the treatment group had a significantly lower overall incidence of respiratory distress morbidity 7.9% versus 23% in non-treated group mainly with TTN (7% versus 19.6% in non-treated group, p-value = 0.009*). Meanwhile; according to the degree of respiratory distress there was significantly lower incidence of both mild and moderate degrees of respiratory distress in the treatment group (7% and 0.9%, respectively) to be (17% and 5.3% respectively) in the control group. Conclusion: The effect of prophylactic corticosteroids administration before elective CS at term looks to be promising in reducing neonatal respiratory morbidity.    

DOI

10.21608/scumj.2012.54794

Keywords

Corticosteroids, RDS, TTN, Elective CS

Authors

First Name

Magdy

Last Name

Ahmed

MiddleName

R

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University

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Volume

15

Article Issue

2

Related Issue

7460

Issue Date

2012-10-01

Receive Date

2019-10-23

Publish Date

2012-10-01

Page Start

32

Page End

39

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_54794.html

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https://scumj.journals.ekb.eg/service?article_code=54794

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5

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023