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54674

Prevalence of Minimal Hepatic Encephalopathy among Chronic Hepatitis C Patients and Assessment of their Response to Lactulose

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Last updated: 04 Jan 2025

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Abstract

Background: Minimal hepatic encephalopathy (MHE) impairs quality of life and predicts overt hepatic encephalopathy in cirrhotic patients. Diagnosis of MHE requires cumbersome tests. Lactulose is effective in the treatment of MHE. Aim: This study aimed to detect the prevalence of (MHE) among chronic hepatitis C patients and assessment of the response of MHE patient's to treatment with lactulose after one month. Patients and Methods: One hundred and fifty six patients were evaluated by psychometry (number connection tests A, B or figure connection tests A, B), venous ammonia, and critical flicker frequency (CFF). MHE was diagnosed by abnormal psychometry (>2SD age matched controls) and abnormal CFF (CFF was considered abnormal when the value was <39 Hz). MHE patients were treated with lactulose for one month. Response was defined by normalization (<2SD of matched controls) of both psychometry and CFF (>39 Hz). Results: Of the 156 patients (age was 44.6±12.3 years, M:F was 52.8:47.2), Child Turcott Pugh groups A:B:C were 47:31:22, 116 (74.4%) had abnormal results of psychometric tests, and 111 (71.2%) had abnormal CFF. One hundred and two (65.4%) patients were diagnosed as having MHE. Child groups A:B:C among thus patients was 33:37:30. The percentage of MHE in different Child groups A, B & C was 46.6%, 79.2%& 86% respectively. After treatment for one month, 69 (67.6%) patients recovered, while 33 (32.3%) continued to have MHE. Conclusion: MHE is prevalent among patient with CHC especially among child B and C groups of patients. Lactulose is effective in the treatment of MHE.  

DOI

10.21608/scumj.2012.54674

Keywords

HCV, critical flicker frequency, psychometric tests

Authors

First Name

Mahmoud

Last Name

Sheded

MiddleName

M

Affiliation

Department of Infectious & Endemic disease, Faculty of Medicine, Suez Canal University, Egypt.

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City

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Orcid

-

First Name

Fawzy

Last Name

Kalil

MiddleName

A

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

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City

-

Orcid

-

First Name

Yossri

Last Name

Ashour

MiddleName

A

Affiliation

Department of Neurology, Faculty of Medicine, Suez Canal University, Egypt

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Orcid

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Volume

15

Article Issue

1

Related Issue

7459

Issue Date

2012-03-01

Receive Date

2019-10-23

Publish Date

2012-03-01

Page Start

30

Page End

38

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 15_Issue 1_Pages 30-38.pdf

PDF . 175.8kB

Link

https://scumj.journals.ekb.eg/article_54674.html

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https://scumj.journals.ekb.eg/service?article_code=54674

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Prevalence of Minimal Hepatic Encephalopathy among Chronic Hepatitis C Patients and Assessment of their Response to Lactulose

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Article

Created At

22 Jan 2023