ManageChatDiscover
54219

Evaluation of Effect of Low-Density Lipoprotein Levels on the Measurement of Hepatitis C Viral Load in Chronic Hepatitis C Patients

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Low density lipoprotein receptor (LDLR) has been proposed as a candidate receptor for hepatitis C virus (HCV). Free beta-lipoproteins in a human serum may regulate the rate of hepatocyte infection by competing with the virus. Therefore, serum HCV levels should be regulated by rise and fall of serum beta-lipoproteins since the infection rate of virions influences HCV replication in hepatocytes and release of virions by hepatocytes. Aim: To evaluate effect of low-density lipoprotein levels on the measurement of hepatitis C viral load in chronic hepatitis C patients and estimate the levels of viral load of hepatitis C in relation to variation of the corresponding low-density lipoprotein levels in chronic hepatitis C patients and their relations to each other. Subjects and Methods: 30 HCV hyperlipidemic patients were subjected to clinical evaluation and laboratory investigations included follow up by repeated measurements of LDL level, AST, ALT, and Albumin for patient selection. Results: There was an inverse statistically significant correlation (r = -0.388, p=0.034) between the HCV RNA absolute viral load differences and LDL level absolute differences (the lower the LDL differences, the higher the HCV RNA differences). Also, there was an inverse statistically significant correlation (r=-0.42, p=0.021) between HCV RNA absolute differences and LDL level percent differences (the higher the LDL percent differences, the lower the HCV RNA absolute differences).The predictive variables for HCV RNA viral load level differences were LDL level differences and LDL percent differences whereas AST, ALT, and Albumin differences were not. Conclusion: Low-density lipoprotein levels have an effect on the measurement of hepatitis C viral load in chronic hepatitis C patients. Therefore, this must be taken in consideration when chronic hepatitis C patients have a history of dyslipidemia and perform a HCV RNA viral load by PCR.  

DOI

10.21608/scumj.2013.54219

Keywords

HCV, LDLR, LDL-cholesterol

Authors

First Name

Basma

Last Name

Hasan

MiddleName

B

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

basmabdr@yahoo.com

City

-

Orcid

-

First Name

Essam

Last Name

Abdalla

MiddleName

M

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Abdul Malek

Last Name

Nasar

MiddleName

M

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Nahed

Last Name

Youssef

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

El Hawary

MiddleName

A

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

16

Article Issue

2

Related Issue

6820

Issue Date

2013-10-01

Receive Date

2019-10-20

Publish Date

2013-10-01

Page Start

87

Page End

93

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 16_Issue 2_Pages 87-93.pdf

PDF . 846.7kB

Link

https://scumj.journals.ekb.eg/article_54219.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=54219

Order

2

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Evaluation of Effect of Low-Density Lipoprotein Levels on the Measurement of Hepatitis C Viral Load in Chronic Hepatitis C Patients

Details

Type

Article

Created At

22 Jan 2023