Beta
ManageSearchChatDiscover
45662

Effect of Stem Cells Injection in Adult Male Albino Rats with Streptozotocin-Induced Diabetic Nephropathy

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Diabetic Nephropathy is a leading cause of end-stage renal disease and the most frequent cause of mortality in patients with diabetes. Therefore, it is extremely important to identify novel interventions to halt the progression of diabetic nephropathy. Aim: This study investigated the effect of human umbilical cord blood (HUCB) derived (CD34+) stem cells therapy on renal morphologic and functional changes and alterations of kidney enzyme levels in streptozotocin (STZ)-induced diabetic nephropathy in rats. Materials and Methods: Sixty adult male albino rats were included in this study and were randomly and equally divided into three groups. Group 'A' was the control, group 'B' was treated with STZ (65 mg/kg, IP) only and group 'C' was treated with STZ and HUCB CD34+ stem cells (1 x 106 cells/ rat, IV). Results: Intravenous injection of CD34+ cells caused significant improvement in blood glucose level (438.3±67 mg/dl of group B vs. 141.8±23.4 mg/dl of group C, p < 0.01). Serum urea and creatinine levels were significantly lower of group C than group B. The levels of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) enzymes in the kidney tissues were significantly lower of group C than group B. Histopathology of the kidney showed much better recovery of group C than group B. Conclusion: HUCB CD34+ cells transplantation in diabetic rats is able to improve blood glucose level, partially ameliorate the renal damage in diabetic rats and consequently improve renal function, renal histology and renal enzyme levels alteration.  

DOI

10.21608/scumj.2013.45662

Keywords

diabetes, human umbilical cord blood, renal enzymatic alteration

Authors

First Name

Kumlachew

Last Name

Dissassa

MiddleName

D

Affiliation

Department of Anatomy, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

Ali

MiddleName

-

Affiliation

Department of Anatomy, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

A Hussain

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Port Said University, Egypt,

Email

mona2002dr@yahoo.com

City

-

Orcid

-

First Name

Alaa El-Din

Last Name

Abd Al-Hamid

MiddleName

S

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

16

Article Issue

1

Related Issue

6819

Issue Date

2013-03-01

Receive Date

2019-08-23

Publish Date

2013-03-01

Page Start

52

Page End

61

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 16_Issue 1_Pages 52-61.pdf

PDF . 492.7kB

Link

https://scumj.journals.ekb.eg/article_45662.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=45662

Order

7

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023