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45653

Vitamin C Antioxidant Effects in Brain of Albino Mice after Seizures and Status Epilepticus Induced by Pentylene-tetrazole (PTZ)

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Last updated: 04 Jan 2025

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Abstract

Oxidative stress has been implicated in the neurological diseases, one of them is epilepsy. Therefore, this study was conducted to determine the effect of vitamin C as an acute antioxidant protective treatment of epilepsy in mice. Materials and Methods: Seventy-eight male albino mice were divided into six groups. The first group was a normal control group that received NaCl, 0.9% (i.p.). The second group received PTZ (65 mg/kg, i.p.) as a single convulsive dose. The third and fourth groups received vitamin C (500 mg/kg/day, i.p.) and vitamin C (1000mg/kg, i.p.) respectively. The fifth and sixth groups received vitamin C (500 mg/kg/day, i.p.) and vitamin C (1000 mg/kg, i.p.) respectively, then after 30 minutes both received Pentylenetetrazole (PTZ) (65 mg/kg i.p.) as a single convulsive dose. Behavioral assessment was done immediately after injections using Racine scale and rotarod tests then after 24 hours, the animals were killed and brain tissue homogenates were prepared to measure lipid peroxide (Malondialdehyde) and catalase activity. Results: Vitamin C showed decreased percentage of seizures, prolonged latency to 1st seizure, improved motor coordination, decreased lipid peroxide level and increased catalase activity. No difference in results between groups received vitamin C (500 mg/kg, i.p.) or (1000 mg/kg, i.p.). Conclusion: Vitamin C was proven to be a potential candidate for decreasing risk of epilepsy.

DOI

10.21608/scumj.2013.45653

Keywords

Oxidative Stress, Epilepsy, MDA, catalase

Authors

First Name

Dina

Last Name

Ali

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

dodi_karim@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Ewais

MiddleName

M

Affiliation

Department of Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Cherine

Last Name

Khalil

MiddleName

M

Affiliation

Department of Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Cherry

Last Name

Kamel

MiddleName

N

Affiliation

Department of Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

Volume

16

Article Issue

1

Related Issue

6819

Issue Date

2013-03-01

Receive Date

2019-08-23

Publish Date

2013-03-01

Page Start

11

Page End

17

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 16_Issue 1_Pages 11-17.pdf

PDF . 193.7kB

Link

https://scumj.journals.ekb.eg/article_45653.html

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https://scumj.journals.ekb.eg/service?article_code=45653

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Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Vitamin C Antioxidant Effects in Brain of Albino Mice after Seizures and Status Epilepticus Induced by Pentylene-tetrazole (PTZ)

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Type

Article

Created At

22 Jan 2023