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46493

The Impact of Recombinant Human Erythropoietin Treatment on Motor Impairment in Rotenone-Induced Parkinsonism in Rats

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Last updated: 04 Jan 2025

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Abstract

Background: Parkinson's disease is a neurodegenerative disease mainly characterized by loss of dopaminergic neurons in the substantia nigra pars compacta and their terminals in the striatum. The development of neuroprotective drugs that slow or delay neurodegeneration became of a considerable interest. In numerous animal models, exogenously administered EPO exhibits neuroprotective effects. Aim: The current research investigated the impact of administration of recombinant human EPO (rhEPO) in rotenone parkinsonian rats. Materials and Methods: Thirty two adult male albino Sprague-Dawly rats were equally and randomly divided into four groups; group 1 the vehicle-treated group, group 2 rotenone-treated group, group 3 treated with rotenone in addition to intranasal rhEPO and group 4 treated with rotenone in addition to intraperitoneal rhEPO. The motor performance of the rats was evaluated. Malondialdehyde and reduced glutathione were assayed. Blood indices were measured. Histopathology of the substantia nigra was also done. Results: Results showed that rotenone-treated rats exhibited significant impairment of motor coordination and marked degeneration of substantia nigra neurons was observed. Both intranasal and intraperitoneal rhEPO treatment improved the motor deficit and significantly increased the number of neurons in the SNpc. intraperitoneal rhEPO significantly increased lipid peroxide and significantly affected blood indices. Conclusion: Our findings suggest that, EPO may have neuroprotective effect in PD. Systemic rhEPO neuroprotective effects may be attenuated by its adverse effects such as increase of OS in the vascular system and stimulation of erythropoiesis. Small doses of intranasal EPO may be sufficient to produce neuroprotection without affecting erythropoiesis and further researches are required to address the mechanisms of neuroprotective effects of EPO.

DOI

10.21608/scumj.2014.46493

Keywords

neuroprotection, Oxidative Stress, Neurodegeneration

Authors

First Name

Dalia

Last Name

Abd-Elhalim

MiddleName

M

Affiliation

Department of Medical Physiology, Faculty of Medicine, Suez Canal University

Email

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Orcid

-

First Name

Mona

Last Name

Hussain

MiddleName

-

Affiliation

Department of Medical Physiology, Faculty of Medicine, Port Said University, Egypt,

Email

mona2002dr@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdo

MiddleName

-

Affiliation

Department of Medical Physiology, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

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Volume

17

Article Issue

2

Related Issue

6818

Issue Date

2014-10-01

Receive Date

2019-08-30

Publish Date

2014-10-01

Page Start

117

Page End

130

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 17_Issue 2_Pages 117-130.pdf

PDF . 548.6kB

Link

https://scumj.journals.ekb.eg/article_46493.html

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https://scumj.journals.ekb.eg/service?article_code=46493

Order

6

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

The Impact of Recombinant Human Erythropoietin Treatment on Motor Impairment in Rotenone-Induced Parkinsonism in Rats

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Article

Created At

22 Jan 2023