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46466

Serum Level of Beta 2 Microglobulin in End Stage Renal Disease Patients with Pruritus

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Last updated: 04 Jan 2025

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Abstract

Background: Etiology of uremic pruritus as a common complication in patients with end stage renal disease (ESRD) is not fully understood. Aim: Our aim was to highlight beta 2 microglobulin (β2M) as a risk factor for uremic pruritus and to assess the diagnostic performance of β2M for predicting pruritus in patients with ESRD. We assessed the serum level of β2M in hemodialysis patients with pruritus compared to those without pruritus. Subjects and Methods: This study included 17 ESRD patients on hemodialysis with pruritus and 17 ESRD patients on hemodialysis without pruritus. Patients included in this study were subjected to detailed history taking, assessment of pruritus severity using visual analog scale (VAS) in pruritic group, kidney function test and estimation of serum β2M levels. Results: The pre-dialysis serum level of β2M was significantly higher in pruritic group than in nonpruritic group (2.79±1.20 and 1.52±0.66, respectively, p=0.002). The post-dialysis serum level of β2M was also significantly higher in pruritic group than in nonpruritic group (3.44±1.31 and 1.89±0.62 respectively, p=0.001). The diagnostic performance of β2M for predicting pruritus in patients with ESRD was good as evidenced by area under the curve (AUC: 81.7, p=0.0001). Best cut off point for predicting pruritus in ESRD was >2.05 in pre-dialysis and >2.66 in post-dialysis. Conclusion: Our results showed high serum level of β2M in ESRD patients with pruritus that may highlight the role of β2M in the pathogenesis of this important problem. β2M has good diagnostic performance of for predicting pruritus in patients with ESRD.

DOI

10.21608/scumj.2014.46466

Keywords

Uremic pruritus, middle molecules, beta 2 microglobulin

Authors

First Name

Haidy

Last Name

Rashad

MiddleName

-

Affiliation

Department of Dermatology & Venereology, Faculty of Medicine, Suez Canal University

Email

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City

-

Orcid

-

First Name

Mona

Last Name

Atwa

MiddleName

-

Affiliation

Department of Dermatology & Venereology, Faculty of Medicine, Suez Canal University

Email

atwamona@gmail.com

City

-

Orcid

-

First Name

Basma

Last Name

Hassan

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Roshdy

Last Name

Mohammed

MiddleName

-

Affiliation

Department of Dermatology & Venereology, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Gamal

Last Name

Tawfik

MiddleName

-

Affiliation

Department of Internal Medicine, Nephrology unit, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

Volume

17

Article Issue

2

Related Issue

6818

Issue Date

2014-10-01

Receive Date

2019-08-29

Publish Date

2014-10-01

Page Start

86

Page End

92

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 17_Issue 2_Pages 86-92.pdf

PDF . 204.8kB

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https://scumj.journals.ekb.eg/article_46466.html

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https://scumj.journals.ekb.eg/service?article_code=46466

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Serum Level of Beta 2 Microglobulin in End Stage Renal Disease Patients with Pruritus

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Article

Created At

22 Jan 2023