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46458

MicroRNA Applications in Human Cancers

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Last updated: 04 Jan 2025

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Abstract

Over the last decade, a family of noncoding RNA molecules, including microRNA (miRNA) has been discovered. MiRNAs have been implicated as key regulators of different cellular processes many of which are associated with cancer. They contribute to the pathogenesis of human cancers; in addition, they may function as oncogenes or tumor suppressors in tumor development. The unique expression profile of microRNAs in different types and subsets of tumor, besides to their possible identification in biological fluids indicate that they might serve as molecular biomarkers for cancer diagnosis, prognosis, and prediction of therapeutic responses. However, they should achieve remarkable sensitivity and specificity, reproducibility and consistency between different studies. Accumulating evidence suggests that alterations of miRNAs expression may ultimately yield new therapeutic strategies against cancer or at least guide clinical decision making. The current review will give an overview on miRNAs, with a focus on their applications in human cancer diagnosis, prognosis, and therapy.

DOI

10.21608/scumj.2014.46458

Keywords

cancer therapy, microRNA, tumorogenesis

Authors

First Name

Ola

Last Name

Leheta

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Egypt , Academic Quality Unit, College of Medicine, King Saud University, KSA

Email

olaleheta@yahoo.com

City

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Orcid

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First Name

Gehan

Last Name

Ibrahim

MiddleName

-

Affiliation

Medical Biochemistry Department, Faculty of Medicine, Suez Canal University, Egypt , Basic Sciences Department, College of Medicine, Princess Nora University, KSA

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Volume

17

Article Issue

2

Related Issue

6818

Issue Date

2014-10-01

Receive Date

2019-08-29

Publish Date

2014-10-01

Page Start

75

Page End

85

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 17_Issue 2_Pages 75-85.pdf

PDF . 260.2kB

Link

https://scumj.journals.ekb.eg/article_46458.html

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https://scumj.journals.ekb.eg/service?article_code=46458

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Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

MicroRNA Applications in Human Cancers

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Article

Created At

22 Jan 2023