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116290

Effect of Human Umbilical Cord Derived Mononuclear Cells Transplantation on Ovarian Dysfunction Caused by Methotrexate in Female Rats

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Last updated: 04 Jan 2025

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Abstract

Background: A search for methods to prevent infertility in patients receiving chemotherapy including methotrexate is important. Cell therapies with human embryonic and specific adult stem cells have emerged as an alternative management for various diseases. Aim: To study the effect of human umbilical cord-derived mononuclear cell transplantation on ovarian dysfunction caused by methotrexate in female rats. Methods: the effect of mononuclear cells (MNCs) treatment (IV injection once in the tail vein for diabetic rats in a dose of 150 × 106 MNCs cells/rat) on ovary and uterus pathology, malondialdehyde (MDA) level in the ovary, and follicle-stimulating hormone (FSH) level was assessed after methotrexate treatment. Results: Treatment with MNCs in rats pretreated with methotrexate significantly improved all parameters measured (body weight, the ratio between ovary and body weight, the ratio between uterus and body weight), level of MDA in ovary tissue, FSH, and histopathology of ovary and uterus as compared to methotrexate only treated rats. Conclusion: These data indicate that MNCs treatment improved ovarian dysfunction associated with methotrexate therapy.

DOI

10.21608/scumj.2016.116290

Keywords

FSH, follicle-stimulating hormone, MDA, Malondialdehyde, Chemotherapy, reproductive organs

Authors

First Name

Reham

Last Name

Masoud

MiddleName

E

Affiliation

Department of Clinical Pharmacology, Faculty of Medicine, Port Said University

Email

rehame_ph@yahoo.com

City

-

Orcid

-

First Name

Amira

Last Name

Mohammed

MiddleName

S

Affiliation

Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, Egypt

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Volume

19

Article Issue

2

Related Issue

6814

Issue Date

2016-10-01

Receive Date

2020-09-30

Publish Date

2016-10-01

Page Start

159

Page End

166

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 19_Issue 2_Pages 159-166.pdf

PDF . 816.3kB

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https://scumj.journals.ekb.eg/article_116290.html

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https://scumj.journals.ekb.eg/service?article_code=116290

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6

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Effect of Human Umbilical Cord Derived Mononuclear Cells Transplantation on Ovarian Dysfunction Caused by Methotrexate in Female Rats

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Article

Created At

22 Jan 2023