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43975

Assessment of Immunoglobulin-E and Interleukin-4 Levels in Papular Urticaria Patients

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Last updated: 22 Jan 2023

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Abstract

Background: Papular urticaria is a common and often annoying disorder manifested by chronic papules caused by a hypersensitivity reaction. The link between atopic immune responses (high serum IgE, IL-4) and the development of rash is clear and has been extensively evaluated in the literature. Aim: This study was designed to find possible co relation between serum levels of IgE and IL-4 and popular urticaria. Patient and Methods: A case control study was done that included 30 patients and 30 controls who were selected randomly according to the eligibility criteria. Assessment of serum IG-E and IL-4 levels was evaluated using sandwich ELISA approach. Results:  Twenty-six patients (87%) have borderline level of IgE, 1 (3%) have high level, while normal IgE level was found in 3 (10%). In the control group, 3 subjects (10%) have borderline level of IgE and 27 (90%) have normal level, while no subject had high IgE level were found. Conclusions: The present study confirmed the significantly higher values of serum IgE and IL-4 in papular urticaria patients. There was statistically significant correlation between the IL-4 and IgE levels in papularr urticaria patients.  

DOI

10.21608/scumj.2016.43975

Keywords

Atopy, Hypersensitivity, Urticaria, Ig-E, IL-4

Authors

First Name

Doaa

Last Name

Ewais

MiddleName

A

Affiliation

Department of Dermatology and Venereolgy, Faculty of Medicine, Suez Canal University, Egypt

Email

doaaewais@yahoo.com

City

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Orcid

-

First Name

Moustafa

Last Name

Eyada

MiddleName

M

Affiliation

Department of Dermatology and Venereolgy, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Fadia

Last Name

Attia

MiddleName

M

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Amal

Last Name

Ahmed

MiddleName

H

Affiliation

Department of Dermatology and Venereolgy, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

19

Article Issue

1

Related Issue

6813

Issue Date

2016-03-01

Receive Date

2019-08-05

Publish Date

2016-03-01

Page Start

101

Page End

106

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 19_Issue 1_Pages 101-106.pdf

PDF . 535.2kB

Link

https://scumj.journals.ekb.eg/article_43975.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=43975

Order

11

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023