Beta
ManageChatDiscover
43969

Assessment of Vitamin D and Parathyroid Hormone in Type 2 Diabetes Mellitus

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Vitamin D deficiency has been proposed as a risk factor for diabetes mellitus type 2(DM type 2). Insulin receptor gene expression and insulin secretion are modulated by vitamin D, indicating their role in the pathogenesis and development of DM type 2. Furthermore, elevated PTH levels may play a role in the etiology of metabolic syndrome (MS), through an association with its individual components or via insulin resistance. Aim: This study aimed to investigate the role of vitamin D and parathyroid hormone in glycemic control of DM type 2. Materials and Methods: The study included 90 participants: 6o patients diagnosed as DM type 2 and 30 healthy age and sex-matched subjects as control. All studied subjects underwent full history taking and complete physical examination. Laboratory tests included fasting blood sugar (FBS), HbA1c, lipid profile, vitamin D and parathyroid hormone serum levels. Results: As regard 25(OH) vitamin D levels, 78.33% of patients were deficient or insufficient, compared to 20% of control subjects that were deficient or insufficient. 25(OH) vitamin D levels showed a significant negative correlation with age (p= 0.002), weight (p=0.0001), BMI (p=0.0001) , FBG (p=0.0001), HbA1C (p=0.0001) and TG (p=0.002). Along with a significant positive correlation with HDL-C (p= 0.0001). PTH levels showed a significant negative correlation with HDL-c (P= 0.0001), 25(OH) vitamin D (P=0.001), in addition to a significant positive correlation with weight (P=0.0001), BMI (P=0.0001), FBG (P=0.005) and HbA1c (P=0.0001). Conclusion: Not only vitamin D but also parathyroid hormone may play a role in glycemic control in patients with DM Type 2  

DOI

10.21608/scumj.2016.43969

Keywords

vitamin D deficiency, Insulin receptor gene, Metabolic syndrome

Authors

First Name

Enas

Last Name

Elkhamisy

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Neven

Last Name

Abbas

MiddleName

F

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt

Email

nevenfarouk45@hotmail.com

City

-

Orcid

-

First Name

Rasha

Last Name

Elzehery

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

Volume

19

Article Issue

1

Related Issue

6813

Issue Date

2016-03-01

Receive Date

2019-08-05

Publish Date

2016-03-01

Page Start

76

Page End

86

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 19_Issue 1_Pages 76-86.pdf

PDF . 674.1kB

Link

https://scumj.journals.ekb.eg/article_43969.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=43969

Order

9

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of Vitamin D and Parathyroid Hormone in Type 2 Diabetes Mellitus

Details

Type

Article

Created At

22 Jan 2023