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43948

Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital

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Last updated: 22 Jan 2023

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Abstract

Background: Chronic hepatitis C (CHC) continues to be a public health problem in Egypt with data suggesting that its incidence may be increasing. Hepatitis C virus (HCV) infection has been associated with a variety of extra-hepatic manifestations, including autoimmune disorders. Aim: To assess the prevalence of autoimmune neutropenia (AIN) in chronic liver disease (CLD) patients with HCV. Patients and Methods: A case-control design was used to fulfill the study objective. It was conducted on 60 subjects, divided into 2 groups: group 1 (30 HCV-infected patients with low total leucocytic count [TLC] as a study group) and group 2 (30 HCV-infected patients with normal TLC as a control group). AIN was evaluated by granulocyte immuno-fluorescence test (GIFT) to detect auto-antibodies against neutrophils in HCV-infected patients presented with neutropenia. Results: The mean age of the first group was 49.9±11.6 years, while the mean age of the second group was 52.7±11.3 years. Male gender was found in 53.3% of the low TLC group compared to 63.3% in normal TLC group; Positive GIFT was found in 13.3% of study group; while none of the control group has positive GIFT. The significant variables among patients with low TLC included low ANC (OR: 5.0, 95% CI: 1.5-16.5, low HB (OR: 7.0, 95% CI: 1.4-35.5), and low PLT count (OR: 15.5, 95% CI: 3.8-63.3). Conclusion:AIN is significantly higher among CHC patients with low TLC compared to normal TLC patients.  

DOI

10.21608/scumj.2016.43948

Keywords

low total leucocytic count, Granulocyte Immuno-Fluorescence Test

Authors

First Name

Nashaat

Last Name

Soliman

MiddleName

M

Affiliation

Departments of Infectious and Endemic Diseases Faculty of Medicine, Suez Canal University, Egypt

Email

nhawass@yahoo.com

City

-

Orcid

-

First Name

Fikry

Last Name

Gobran

MiddleName

-

Affiliation

Departments of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Fadia

Last Name

Attia

MiddleName

M

Affiliation

Departments of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Nashwa

Last Name

Elessawy

MiddleName

R

Affiliation

Departments of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

Volume

19

Article Issue

1

Related Issue

6813

Issue Date

2016-03-01

Receive Date

2019-08-05

Publish Date

2016-03-01

Page Start

60

Page End

67

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 19_Issue 1_Pages 60-67.pdf

PDF . 639.9kB

Link

https://scumj.journals.ekb.eg/article_43948.html

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https://scumj.journals.ekb.eg/service?article_code=43948

Order

7

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023