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43911

Association of RS 7903146 (C/T) Single Nucleotide Polymorphism at Transcription Factor 7 Like 2 Gene with Type 2 Diabetes Mellitus in Egyptian Patients

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Last updated: 22 Jan 2023

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Abstract

Background: Many loci were found to be associated with type 2 diabetes mellitus (T2DM) risk as single nucleotide polymorphism (SNP) at the transcription factor 7-like 2 gene (TCF7L2) locus on chromosome 10q (rs7903146) [C/T]. Aim: Estimation of the association of this gene polymorphism with T2DM and its complications in Egyptian population. Patients and Methods: This study was done, using 90 Egyptian T2DM patients and 100 controls. This polymorphism was genotyped by conventional PCR. Measurement of blood glucose, glycated hemoglobin (HbA1c), lipid profile, and microalbuminuria were performed for the study subjects using standard methods. Body Mass index and fundus examination for detection of diabetic retinopathy were also done. Results: The genotype and allele frequencies in TCF7L2 rs7903146 were nearly the same in the patient and control groups (P > 0.05).Odds Ratio for the high risk allele (T) of (rs7903146) was (OR) = 0.97 with 95% confidence interval (CI) from 0.61 to 1.54 with the P = 0.9. Conclusion: These data suggest that the TCF7L2 SNP rs7903146 may not significantly contribute to T2DM susceptibility in Egyptian population. 

DOI

10.21608/scumj.2016.43911

Keywords

Allele specific PCR, Wnt signaling pathway, Suez Canal University Hospital

Authors

First Name

Nahed

Last Name

Abd El Razek

MiddleName

Y

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

nahedyoussef2003@yahoo.com

City

-

Orcid

-

First Name

Neveen

Last Name

Wissa

MiddleName

R

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Hassnaa

Last Name

Nassar

MiddleName

M

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Seham

Last Name

Omar

MiddleName

A

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

19

Article Issue

1

Related Issue

6813

Issue Date

2016-03-01

Receive Date

2019-08-05

Publish Date

2016-03-01

Page Start

29

Page End

38

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 19_Issue 1_Pages 29-38.pdf

PDF . 926.6kB

Link

https://scumj.journals.ekb.eg/article_43911.html

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https://scumj.journals.ekb.eg/service?article_code=43911

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

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https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023