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43563

Association of Leptin Gene G2548A Polymorphism and Leptin Resistance with Insulin Resistance and Obesity among Egyptians

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Last updated: 22 Jan 2023

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Abstract

Background leptin (LEP) and leptin receptor (LEPR) genes have been correlated to the pathophysiology of obesity, diabetes, metabolic syndrome and associated complications. LEP G2548A (rs7799039) is a single nucleotide polymorphism (SNP) in leptin gene, the association between G2548A and increased leptinemia is controversial.Aim to study the correlation between LEP G2548A and leptin resistance and their accompaniment with insulin resistance among obese Egyptians. Patients & Methods:Forty-four obese patients and 44 normal controls were included, and polymerase chain reaction restriction fragment length polymorphism method were used. Serum lipid profile, blood glucose, serum leptin and insulin were also measured. Results Statistically significant positive correlations between insulin resistance and age, diabetes mellitus, hypertension, family history of cardiac disease, hyperlipidemia, family history of obesity, BMI, serum cholesterol, serum triglycerides, serum LDL cholesterol and allele G (for all p-value =0.0001 except cardiac disease p-value =0.006 and allele G p-value=0.001) were found. The percentages of heterozygous AG and homozygous AA genotypes were statistically significantly higher among obese group than among non-obese group (52.3% and 25% vs. 18.2 and 2.3%, respectively) (p=0.001). In contrast, non-obese group showed statistically significant higher percentage of homozygous genotype GG (Wild type) in comparison to obese group (79.5% vs. 25%, respectively) which is statistically significant (p=0.001). ConclusionCurrent results concluded that leptin gene G2548A polymorphism could be a genetic marker of obesity in Egypt. The correlation between (SNP) in the leptin gene (G2548A) and insulin resistance among obese Egyptians would help in improving knowledge and management of obesity among Egyptian patients.

DOI

10.21608/scumj.2017.43563

Keywords

SNP, PCR, RFLP, Body Mass Index

Authors

First Name

Sara

Last Name

Aboelros

MiddleName

A

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

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City

-

Orcid

-

First Name

Abdel Malik

Last Name

Nassar

MiddleName

M

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

El shabrawy

MiddleName

M

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Ranya

Last Name

Hassan

MiddleName

M

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

ranyamoustafa@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdelellah

MiddleName

T

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt

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-

City

-

Orcid

-

Volume

20

Article Issue

2

Related Issue

6812

Issue Date

2017-10-01

Receive Date

2019-08-02

Publish Date

2017-10-01

Page Start

142

Page End

152

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 20_Issue 2_Pages 142-152.pdf

PDF . 800.8kB

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https://scumj.journals.ekb.eg/article_43563.html

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https://scumj.journals.ekb.eg/service?article_code=43563

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023