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43357

Estimation of Clusterin Role as a Biomarker for Virus C-related Hepatocellular Carcinoma

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Last updated: 04 Jan 2025

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Abstract

Background: More than 500,000 new patients are diagnosed every year with hepatocellular carcinoma (HCC) worldwide. Clusterin (apolipoprotein J) is a multifunctional glycoprotein that exists in almost all mammalian tissue and most human body fluids. Recently, few studies have been done to evaluate serum clusterin role as a biomarker for diagnosis viral related hepatocellular carcinoma.Aim: The aim of this study is to evaluate the potential usefulness of clusterin as a new biomarker for diagnosing virus C-related hepatocellular carcinoma.Subjects and Methods: Twenty-nine patients with HCC, twenty-nine patients with liver cirrhosis and thirty healthy controls were enrolled in the study. Estimation of serum clusterin was done by enzyme linked immunosorbent assay (ELISA). Alanine aminotransferase (ALT) activity, aspartate aminotransferase (AST) activity, albumin level, bilirubin level as well as creatinine level were measured in serum by routine enzymatic method. Sera were stored at -20˚C to measure alpha fetoprotein (AFP) concentration and clusterin concentration.Results: Serum clusterin level was not significantly elevated in patients with HCC (p>0.05). Receiver operator curve showed that AFP had a greater area under curve value (0.92) than that of clusterin (0.58)Conclusion: our study concluded that AFP is still the gold standard tumor biomarker for HCV related HCC, and that it can be used in conjunction with ultrasonography in the early detection of HCC instead of serum clusterin.

DOI

10.21608/scumj.2018.43357

Keywords

Alpha fetoprotein, Hepatitis C virus related liver cirrhosis, liver cancer

Authors

First Name

Mohy-Eldin

Last Name

Abdel-Atti

MiddleName

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Affiliation

Department of Organic chemistry, Faculty of science, Suez Canal university, Ismailia, Egypt

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Orcid

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First Name

Dahlia

Last Name

Badran

MiddleName

I

Affiliation

Department of Medical biochemistry, Faculty of Medicine, Suez Canal university, Ismailia, Egypt

Email

dahliabadran@hotmail.com

City

-

Orcid

0000-0002-8234-2674

First Name

Ohoud

Last Name

Marie

MiddleName

M

Affiliation

Department of Biochemistry, Faculty of Science, Suez Canal university, Ismailia, Egypt

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Orcid

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Volume

21

Article Issue

1

Related Issue

6788

Issue Date

2018-03-01

Receive Date

2019-07-31

Publish Date

2018-03-01

Page Start

50

Page End

58

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 21_Issue 1_Pages 50-58.pdf

PDF . 471.1kB

Link

https://scumj.journals.ekb.eg/article_43357.html

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https://scumj.journals.ekb.eg/service?article_code=43357

Order

7

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Estimation of Clusterin Role as a Biomarker for Virus C-related Hepatocellular Carcinoma

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Article

Created At

22 Jan 2023