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43356

Letrozole and Anastrozole in Early Breast Cancer Post-menopausal Patients in Oncology Department at Suez Canal University Hospital

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Last updated: 22 Jan 2023

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Abstract

Background:There are limited data in the literature comparing the efficacy of aromatase inhibitors in postmenopausal hormonal receptor positive early breast cancer patients. Aim: To compare the efficacy of letrozole and anastrozole in hormone-receptor positive postmenopausal breast cancer patients. Patients and Methods: A retrospective study with a mean follow-up period of 64 months (about 5 years) for 74 files of early invasive postmenopausal breast cancer hormonal receptor positive patients; 39 received letrozole and 35 received anastrozole, considering TTP as primary end point, and OS as second end points. Results: Letrozole is not superior to anastrozole during the first 55 months of treatment (80% PFS at 5th year), and 80% OS benefit at 6th year.. Overweight patients had better (90% PFS at 5th year) than obese patients (60% PFS at 5th year). Conclusion: Letrozole is not superior to anastrozole in efficacy in early invasive hormonal receptor positive breast cancer postmenopausal patients during the first 5 years of treatment; however, Letrozole 2nd line after tamoxifen is superior to anastrozole 2nd line after tamoxifen in treating obese patients with early invasive hormone receptor positive breast cancer.

DOI

10.21608/scumj.2018.43356

Keywords

Suvival, TTP, PFS, AI

Authors

First Name

Manar

Last Name

Montasser

MiddleName

-

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

manarmontasser17@gmail.com

City

-

Orcid

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First Name

Ehab

Last Name

Hassanin

MiddleName

M

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Soheir

Last Name

Abdelmohsen

MiddleName

E

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Maha

Last Name

Zamzam

MiddleName

L

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

21

Article Issue

1

Related Issue

6788

Issue Date

2018-03-01

Receive Date

2019-07-31

Publish Date

2018-03-01

Page Start

40

Page End

49

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 21_Issue 1_Pages 40-49.pdf

PDF . 819.0kB

Link

https://scumj.journals.ekb.eg/article_43356.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=43356

Order

6

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023