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43353

Assessment of the Response to an Experimental Dose of Furosemide in Patients with Decompensated Chronic Liver Disease and Ascites

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Last updated: 22 Jan 2023

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Abstract

Background: Ascites due to cirrhosis can be mobilized with a treatment regimen consisting of dietary sodium restriction and oral diuretics. Ascites resistant to diuretic therapy requests adopting balanced approaches in its management but treatment responses are variable and frequently difficult to assess. Aim: To quantify response to an experimental dose of furosemide in patients with decompensated chronic liver disease and ascites. Subjects and Methods: a pre-post intervention study was carried out on 110 patients with ascites grade 2 or 3 receiving IV furosemide, and response was assessed by Absolute and percentage weight loss, the average daily weight loss, average daily urine output and % deviation from the pre-intervention 24-h output, 24h urinary sodium, and fractional excretion of sodium. Results: our study revealed that 42.7% were responders to furosemide, and presence of moderate positive significant correlation between average daily urine output and average daily weight reduction (r = 0.682), also there is significant relationship between baseline urinary sodium level and FENa and diuretic response. Conclusion: This study revealed that the median point for diuretic response using absolute weight loss is around -0.4kg and average daily urine output around 1500ml, and that there is significant correlation between 24h urinary sodium and diuretic response.

DOI

10.21608/scumj.2018.43353

Keywords

Cirrhosis, urinary sodium, sodium retention, loop diuretics

Authors

First Name

Mohammad

Last Name

Khedr

MiddleName

S

Affiliation

Internal Medicine Department, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohammad

Last Name

Hassan

MiddleName

F

Affiliation

Endemic & Infectious Diseases Department, Faculty of Medicine, Suez Canal University, Egypt

Email

mfmhassan666@yahoo.com

City

-

Orcid

-

First Name

Mohammad

Last Name

Al-Shatouri

MiddleName

A

Affiliation

Radiology Department, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Hanaa

Last Name

Ali

MiddleName

E

Affiliation

Internal Medicine Department, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

21

Article Issue

1

Related Issue

6788

Issue Date

2018-03-01

Receive Date

2019-07-31

Publish Date

2018-03-01

Page Start

24

Page End

30

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 21_Issue 1_Pages 24-30.pdf

PDF . 300.7kB

Link

https://scumj.journals.ekb.eg/article_43353.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=43353

Order

4

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023