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43351

Predictors of Induction and Sustainability of Response to Diuretic Therapy in Patients with Decompensated Chronic Liver Disease

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Last updated: 04 Jan 2025

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Abstract

Background: Factors involved in individual's response to loop diuretics in cirrhotic patients with ascites are many, which renders it difficult to austerely predict response to diuretic therapy in those patients. The aim of this study was to evaluate factors which determine initial response to loop diuretic therapy in those patients and to determine whether such factors can predict a sustained diuresis response. Patients and Methods: One hundred and ten patients with non-malignant chronic liver disease and ascites were treated with IV furosemide in doses according to serum creatinine together with oral spironolactone 50mg twice daily. Before and during the diuretic therapy a set of clinical and laboratory variables were investigated as possible predictive factors influencing the therapeutic response to diuretics. The renal arterial resistive index (RI) (reflecting renal vascular resistance) was estimated with duplex Doppler ultrasonography. Results: Our study revealed statistically significant relation between high ascites grade(p=0.013), higher Child-Pugh class (p< 0.001), higher baseline serum creatinine & lower eGFR (p< 0.001), and high renal resistive index (p=0.002) with poor diuretic response. Conclusion: combining both clinical and laboratory findings together with elevated baseline renal resistive index would be helpful in early identification of the subgroup of patients who are at higher risk of diuretic resistance.

DOI

10.21608/scumj.2018.43351

Keywords

Cirrhosis, urinary sodium, sodium retention, loop diuretics

Authors

First Name

Mohammad

Last Name

Khedr

MiddleName

S

Affiliation

Internal Medicine Department, Faculty of Medicine, Suez Canal University, Egypt

Email

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City

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Orcid

-

First Name

Mohammad

Last Name

Hassan

MiddleName

F

Affiliation

Endemic & Infectious Diseases Department, Faculty of Medicine, Suez Canal University, Egypt

Email

mfmhassan666@yahoo.com

City

-

Orcid

-

First Name

Mohammad

Last Name

Al-Shatouri

MiddleName

A

Affiliation

Radiology Department, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Hanaa

Last Name

Ali

MiddleName

E

Affiliation

Internal Medicine Department, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

21

Article Issue

1

Related Issue

6788

Issue Date

2018-03-01

Receive Date

2019-07-31

Publish Date

2018-03-01

Page Start

18

Page End

23

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 21_Issue 1_Pages 18-23.pdf

PDF . 267.4kB

Link

https://scumj.journals.ekb.eg/article_43351.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=43351

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Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Predictors of Induction and Sustainability of Response to Diuretic Therapy in Patients with Decompensated Chronic Liver Disease

Details

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Article

Created At

22 Jan 2023