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43349

Natural Killer Group 2 Type D (NKG2D) Gene Polymorphism in Systemic Lupus Erythematosus-Suez Canal Region - Egypt

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Last updated: 22 Jan 2023

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Abstract

Background: Natural killer group 2 type D (NKG2D), an activating receptor expressed on Natural Killer (NK), is a type II transmembrane glycoprotein. Normally, the function of NK cells is the eradication of infected or distorted cells and prevention of autoimmunity. The abnormal expression of NKG2D ligands has been found to increase the susceptibility to different autoimmune disorders, including rheumatoid arthritis, multiple sclerosis and autoimmune diabetes mellitus. Aim: to assess the association of NKG2D polymorphism in Egyptian SLE patients dwelling Suez Canal region and its potential clinical correlation.Patients and Methods: NKG2D polymorphism was assessed by using polymerase chain reaction (PCR) in 50 SLE patients and 50 healthy controls and the results were analyzed using allelic discrimination software. Clinical and laboratory manifestations and disease activity using SLE disease activity index (SLEDAI) were also assessed. Results: Our results showed that the frequency of the NKG2D single nucleotide polymorphism (SNP) (rs2255336 Gā†’ A) was not significantly higher in cases of SLE compared to healthy control (p=0.13). NKG2D polymorphism in SLE patients showed a statistical difference between GG genotype versus GA & AA genotypes regarding inflammatory rash, lupus headache and hair loss. Conclusion: NKG2D single nucleotide polymorphism (SNP) seems to play no role in the susceptibility to SLE in Egyptian population of Suez Canal area.

DOI

10.21608/scumj.2018.43349

Keywords

NKG2D, SNP, genotype, SLEDAI

Authors

First Name

Hussam

Last Name

ElBahrawy

MiddleName

M

Affiliation

Department of Biochemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt

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Orcid

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First Name

Mona

Last Name

Ghaly

MiddleName

S

Affiliation

Department of Rheumatology & Rehabilitation, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

xmghaly@gmail.com

City

-

Orcid

-

First Name

Moushira

Last Name

Mahmoud

MiddleName

A

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

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First Name

Samir

Last Name

Abdel-Moneim

MiddleName

M

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

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-

City

-

Orcid

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Volume

21

Article Issue

1

Related Issue

6788

Issue Date

2018-03-01

Receive Date

2019-07-31

Publish Date

2018-03-01

Page Start

11

Page End

17

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 21_Issue 1_Pages 11-17.pdf

PDF . 339.2kB

Link

https://scumj.journals.ekb.eg/article_43349.html

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https://scumj.journals.ekb.eg/service?article_code=43349

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023