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44180

Effect of Lycopene on Bisphenol A-induced Immunological Disturbances in Albino Male Rats

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Last updated: 22 Jan 2023

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Abstract

Background: Bisphenol A (BPA) is a widely used and environmentally spread plasticizer. BPA has various toxic effects, including immunological alterations. Aim: Current work aimed to investigate the effect of BPA and protection with lycopene (LYC) on immunological parameters. Material and Methods: Twenty-four male albino were divided into 4 equal groups. Control group received corn oil, LYC group was given LYC 5 mg/kg,BPA group was given BPA at 5 mg/kg. Last group was given combination of BPA and LYC the same previous doses. Treatments were given daily via oral gavage for 4 weeks. Weight gain, food conversion ratio (FCR), hematological parameters and lymphocytes proliferation assay were determined. Serum total antioxidant capacity (TAC), malondialdehyde (MDA), interleukin-1β (IL-1β), Interleukin-12 (IL-12) and lymphocytes comet assay were evaluated. Spleen and thymus histopathological assessment was done. Results: BPA significantly (P<0.05) increased FCR while decreased lymphocytes proliferation than control group however, hematological parameters didn't alter. Serum TAC was significantly (P<0.05) reduced in BPA group than control group while MDA, IL-1β and IL-12 were significantly (p<0.05) increased than control group. Lymphocyte showed significant increase in comet tail and % of damage. Thymus and spleen revealed mild lymphoid depletion. Conclusion: BPA induced immunological perturbations that favors pro-inflammation and autoimmunity. LYC administration ameliorated oxidative stress and lipid peroxidation induced immunological disorders.
 

DOI

10.21608/scumj.2019.44180

Keywords

antioxidant, bisphenol A, Cytokines, hematology, lycopene

Authors

First Name

Heba

Last Name

Abdelrazek

MiddleName

MA

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.

Email

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-

Orcid

-

First Name

Dalia

Last Name

Eltamany

MiddleName

A

Affiliation

Department Home Economic, Nutrition and Food Science, Faculty of Education, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Soliman

MiddleName

TA

Affiliation

College of Applied Medical Sciences, Department of Medical Laboratory Sciences, University of Bisha, Kingdom of Saudi Arabia.

Email

-

City

-

Orcid

-

First Name

Sahar

Last Name

Greish

MiddleName

M

Affiliation

Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

saharmg@yahoo.com

City

-

Orcid

-

First Name

Hala

Last Name

Ebaid

MiddleName

M

Affiliation

Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

Volume

22

Article Issue

1

Related Issue

6743

Issue Date

2019-03-01

Receive Date

2019-08-07

Publish Date

2019-03-01

Page Start

9

Page End

17

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 22_Issue 1_Pages 9-17.pdf

PDF . 594.9kB

Link

https://scumj.journals.ekb.eg/article_44180.html

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https://scumj.journals.ekb.eg/service?article_code=44180

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023