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43542

Assessment of the Level of Soluble CD25 as a Marker for the Detection of Hepatocellular Carcinoma in Chronic Hepatitis C virus (HCV) Infected Patients

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Last updated: 04 Jan 2025

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Abstract

Background: Hepatitis C virus (HCV) is one of the most potential pathogens all over the world. Egypt has the highest HCV prevalence in the world. The hepatocellular carcinoma (HCC) is among cancers with the poorest outlook. The detection of HCC improves the outcome. The poor sensitivity of AFP underlines the need for a biomarker that can detect HCC. It was found that the CD25 is increased in patients with HCC. Aim: To assess the performance of serum soluble CD25 (sCD25) in the prediction of early HCC and compare it to α-fetoprotein (AFP); the classical biomarker of HCC. Patients and Methods: This study was a descriptive study. Patients were recruited from the Hepatology and Gastro-enterology department at Suez Canal University hospital. The study included 60 subjects, normal healthy individuals (n=20), cirrhotic patients (n=20) and HCC patients (n=20). 2 blood samples were collected from each patient one for liver profile and second stored for sCD25. Liver function tests, AFP and sCD25 were done to all the participants. Results: Our results show a highly significant increased levels of sCD25 in patients with cirrhotic liver and HCC compared to normal controls, (p=0.001). No difference was found in sCD25 levels in HCC patients compared to liver cirrhosis patients (p=0.862). Conclusion: sCD25 can differentiate HCC patients from normal healthy persons but not from cirrhotic patients. Thus, sCD25 cannot be used as an accurate diagnostic marker for HCC.

DOI

10.21608/scumj.2018.43542

Keywords

sCD25, HCC, Liver cirrhosis, hepatitis C

Authors

First Name

Shereen

Last Name

Z. Wagrees

MiddleName

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Affiliation

Department of Clinical Pathology, Suez Canal University, Egypt

Email

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City

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Orcid

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First Name

Hanaa

Last Name

F. Abdelaziz

MiddleName

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Affiliation

Department of Clinical Pathology, Suez Canal University, Egypt

Email

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City

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Orcid

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First Name

Basma

Last Name

Badr EL-Dein

MiddleName

-

Affiliation

Department of Clinical Pathology, Port Said University, Egypt

Email

basmabdr@yahoo.com

City

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Orcid

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First Name

Seham

Last Name

A. Omar

MiddleName

-

Affiliation

Department of Internal Medicine, Suez Canal University, Egypt

Email

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City

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Orcid

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Volume

21

Article Issue

2

Related Issue

6670

Issue Date

2018-10-01

Receive Date

2019-08-01

Publish Date

2018-10-01

Page Start

99

Page End

106

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 21_Issue 2_Pages 99-106.pdf

PDF . 286.1kB

Link

https://scumj.journals.ekb.eg/article_43542.html

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https://scumj.journals.ekb.eg/service?article_code=43542

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6

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of the Level of Soluble CD25 as a Marker for the Detection of Hepatocellular Carcinoma in Chronic Hepatitis C virus (HCV) Infected Patients

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Article

Created At

22 Jan 2023