Management of dyes in the habitat causes considerable damage which can be dangerous in certain marine ecosystems because of their product disintegration, it could be harmful to some aquatic organisms. The textile wastewater coloring pigments may have an esthetic appearance and affect plant photosynthesis. There are several disadvantages to chemical or physical methods that a biological process that saves costs and is environmentally friendly can solve. Absorbents such as bacteria, fungi, cell membranes can be biological methods. Yeast may be less expensive and better than other microorganisms. This research attempted to investigate the decolorization of blue coloring in methylene blue by Saccharomyces cerevisiae. The study was carried out to find the optimum conditions in which the maximum decolorization occurred. The highest decolorization was monitored at 30^oC and a concentration of 100 ppm (0,01g/100ml), during which a maximum decolorization of 95,95% occurred after the 20 h incubation period. In the next assay at concentrations of 100 ppm (0.01g/100 ml) and pH 7 for 20 h, a cumulative decolorization of 98.90% has been obtained at dosages of 0.1 gram/l with 30^oC, which is considered as the best conditions. Saccharomyces cerevisiae was able to handle the textile wastewater in optimal conditions.