Field experiments were conducted to evaluate the effect of five fungicides, one commercial biofungicide and one bioagent against rice blast disease under field conditions during the two summers of consecutive seasons (2020 and 2021). The tested fungicides were Beam (75% WP) tricyclazole, Fuji-one (40% EC) isoprothiolane, Score (25% EC) difenoconazole, Leader (45% EC) prochloraz and Nativo (75% WG) tebuconazole 50 + trifloxystrobin 25 each at two rates (75 and 100 gm, 300 and 400 cm³, 150 and 200 cm³, 300 and 400 cm³ and 150 and 200 gm, 200 L^-1, respectively). The biofungicide Plant guard (30 million cell ml^-1) (Trichoderma harzianum) applied at two rates (375 and 500 ml, 200 L^-1) and the bioagent isolated from soil (Trichoderma harzianum 1×10⁹ spores ×  ml^-1) applied at two rates (375 and 500 ml, 200 L^-1). Each chemical fungicide, biofungicide and isolated bioagent was applied as foliar spraying 2 times per season^-1. The results clearly indicated that chemical fungicides were significantly more effective than the biofungicides and isolated bioagent, and all the tested compounds particularly Nativo (75% WG) and Score (25% EC) significantly reduced incidence and severity of leaf and panicle blast disease in rice and subsequently increased a rice biological yield, grain yield and straw yield in comparison with the untreated control. Also, T. harzianum isolated was more effective than commercial product plant guard. The higher rate of application in all treatments gave higher reduction of the rice blast disease, and subsequently higher yield.