The research aimed to determine the level of knowledge of rural women in dealing with household waste, the level of their practice of dealing with food, clothing, and plastic waste, and the relationship of the studied independent variables to the degree of knowledge of the respondents and the degree of their interaction with the studied household waste. The study was conducted in three villages from Minya al-Qamh Center in Sharkia Governorate on a sample of 400 female respondents from rural women. The interview questionnaire was used to collect data during the period from May to August 2018. After collecting the data, it was unloaded and statistically analyzed using that frequency, percentages, weighted average and correlation coefficient. Pearson's Simple. The most important results were the following: The majority of respondents, 87.2%, have a high level of knowledge of dealing with household waste in general, and the lowest percentage of 5% has a low level of knowledge. The high percentage of respondents in their rational handling of the following food waste: baladi bread 87.5%, fino bread 81%, and leftover fruit 64.8%, and the most important disposal methods were re-use. The high percentage of respondents in their rational handling of the following clothing waste: 92.3% of used clothes, 88.9% of short pants, and 88.6% of old clothes. The high percentage of respondents in their rational handling of the following plastic waste: plastic jerrycans and buckets 84.1%, plastic water bottles 62.6%, and the most important ways to dispose of them were re-use and sale. The significance of the correlation between the variables of cultural openness, innovation, and ambition among the respondents and the degree of their knowledge and handling of the studied household waste.