Desertification is one of the most important problems facing arid and semi-arid regions, whether it is caused by irresponsible human activity or due to natural conditions or both. The objectives of the study were to assess the environmental sensitivity of desertification in the western delta region using a Mediterranean Mathematical Model (MEDALUS). Where the sensitivity of the land to desertification is deduced in this model using geographic information systems through the integration of spatial data of soil characteristics, vegetation cover, climate and management obtained from field visits and laboratory analyzes and then entered into the ArcGIS10.3 program base to derive a map of desertification sensitivity. This map was used by Stakeholders and decision-makers to propose a list of interventions that may contribute to alleviating desertification problems in the region and thus ensure their sustainable use. The results indicated that the sensitivity to desertification in the western delta region is distributed by 88% of medium sensitivity (i.e., 3,405.69 km), while the areas with high sensitivity to desertification represent 12% of the total area (i.e., 462.68 km). The results also indicated that low rainfall and poor soil properties are a determining factor in areas highly sensitive to desertification in the western Delta.