The purpose of the present study was to investigate the effect of a collocation- based program on Promoting EFL Reading Comprehension skills among secondary school students. The researcher hypothesized that the suggested program would be effective in developing interpretive and critical reading comprehension skills. Participants of the study included a group of Second year secondary school students (N=40) from Minya Elkamh secondary school for girls. A reading comprehension pretest posttest was used to obtain data. Design of the study was one group experimental pre-posttest. The material of the study included a collocation- based program. Participants were pre-assessed before treatment. The posttest reading comprehension test was presented to the study sample after intervention Findings were analyzed statistically through the SPSS (Statistical Package for the Social Science) program.  T-value, mean scores, standard deviation and degree of freedom were calculated..  Findings proved the effectiveness of the collocation based program in developing reading comprehension interpretive and critical skills. Recommendations and suggestions for further research were presented.