Nosema disease is regarded one of the causes of Colony Collapse Disorder (CCD). Nowadays, aromatic honey has significant effect in honey bee diseases and it is not unusual, feeding honey bees by aromatic honey for Nosema disease control. Results revealed that feeding honey bee on Anise honey by concentration 150 g/colony have the lowest infection percentage 28.78% then Anise 100 g/colony 32.94% and Anise 50 g/colony 37.89% compared with control 65.11%. In the second place Fennel honey general mean 43.11%. Finally, Marjoram honey general mean 62.76%.     On the other hand, the effect of these aromatic honey samples back to that antioxidant activity of the three types of honeys represented in flavonoids value. The chemical analysis of honey samples was carried out to clarify the beneficial compounds that have an effect on Nosema disease. Results showed that the highest flavonoids value was found in Anise honey (14.02) followed by Fennel honey (9.11) and finally Marjoram honey (8.24).