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151959

Histopathological Studies on the Curative Role of Mentha longifolia in Trypanosoma evansi Experimentally Infected Rats

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Veterinary microbiology and pathobiology (Veterinary Bacteriology & my…irology, immunology, parasitology, pathology, and molecular biology).

Abstract

Trypanosomiasis is an important protozoan disease of domestic animals and man. One of the important pathogenic trypanosomes in animals is Trypanosoma evansi; the causative agent of Surra that is highly fatal to a number of domesticated mammals such as camels. Mentha longifolia is a plant that has been used as traditional medicine to treat some parasitic and microbial diseases in different countries. This study was conducted to evaluate the antitrypanosomal activity of the leaf ethanolic extract of M. longifolia against experimentally induced T. evansi infection in rats. A total of 16 male albino rats were allocated into four groups of four rats each; uninfected control group (CG), plant extract group (PG), trypanosome infected  group (TG), and infected treated group (plant extract + trypanosome) (PTG). Blood and tissue samples were collected from rats on the 35th day after T. evansi infection and treatment. Hematological results obtained from T. evansi-infected rats showed microcytic hypochromic anemia with a significance of (P< 0.05). There was a significant (P< 0.05) increase in the total leukocytic count (TLC) and number of neutrophils, eosinophils, and monocytes in TG) compared to those in CG, PG, and PTG. Histopathological examination revealed necrosis, hydropic degeneration and liver apoptosis, hemorrhage, edema, inflammatory cell infiltration of kidney, demyelination of brain, lymphocytic granuloma of lung. Results of the present study showed that the antitrypanosomal activity of M. longifolia extract was not effective in vivo, despite its high antitrypanosomal activity in vitro. 

DOI

10.21608/jvmr.2021.61380.1033

Keywords

antitrypanosomal activity, Histopathological examination, Mentha longifolia, Rats, Trypanosoma evansi

Authors

First Name

Rasha

Last Name

Mohamed

MiddleName

S.

Affiliation

Animal Health Department, Desert Research Center, Egypt

Email

rashanono2008@yahoo.com

City

cairo

Orcid

-

Volume

27

Article Issue

2

Related Issue

22733

Issue Date

2020-12-01

Receive Date

2021-02-03

Publish Date

2020-12-01

Page Start

177

Page End

189

Print ISSN

2357-0512

Online ISSN

2357-0520

Article File

JVMR_Volume 27_Issue 2_Pages 177-189.pdf

PDF . 2.4MB

Link

https://jvmr.journals.ekb.eg/article_151959.html

Detail API

https://jvmr.journals.ekb.eg/service?article_code=151959

Order

8

Type

Original Article

Type Code

891

Publication Type

Journal

Publication Title

Journal of Veterinary Medical Research

Publication Link

https://jvmr.journals.ekb.eg/

MainTitle

Histopathological Studies on the Curative Role of Mentha longifolia in Trypanosoma evansi Experimentally Infected Rats

Details

Type

Article

Created At

22 Jan 2023