Nasopharyngeal swabs and pnuemonic lung autopsies collected from diseased or slaughtered sheep and goats suffering from respiratory manifestation were subjected to microbiological sreening. In addition, serum samples were collected from all animals were investigated. P. hemolytica was the most prevalent recovered bacterial isolates followed by S. aureus and E. coli. On the other hand, Aspergillus fumigatus was the most prevalent fungus. Aspergillus species and Candida albicans were also isolated. Most of the isolated bacterial strains were found sensitive to spectrama and chloramphenicol. Serodiagnosis of P. hemolytica by ELISA using the whole cell antigen gave positive results in 18.3 and 22.5% of diseased sheep and goats respectively and 52% and 42.1% of slaughtered pneumonic sheep and goats respectively. Also serodiagnosis of Aspergillus fumigatus by indirect haemagglutination test revealed positive results in18.3and 17.5% of diseased sheep and goats respectively and 24% and 21% in sera of slaughtered pneumonic sheep and goats respectively. Histopathological changes due to P. haemolytica and Aspergillus fumigatus were recorded.