An evaluation of the efficacy of different treatment trials in controlling Pseudomonas
aeruginosa infection in quail chicks was done. Two probiotics (Lactobacilli and active dry yeast) and two fluoroquinolone antibiotics (Ciprofloxacin & ofloxacin) were used. Four-daysold quail chicks were infected orally with 0.2ml containing 3 x 108 CFU/ml of Pseudomonas aeruginsa strain which proved to be highly pathogenic for quails and sensitive to both antibiotics mentioned above. After three days, infected quails were sorted out into treated and control groups. The fluoroquinolone treated groups were given either of the antibiotics in the drinking water at a dose level of 10mg/kg BW every 12 h for five successive days, while the probiotic treated groups received either and both of the probiotics at a dose level of 0.5gm/liter
daily till the end of the experiment. The results revealed that fluoroquinolones were highly effective in destroying the infectious agent. on the other hand, the general health condition and body functions were negatively affected. Histopathological changes in fluoroquinolone and probiotic treated groups were similar. Bacteriologically, the probiotics failed to remove pseudomonas from the infected internal organs. Probiotics proved to be effective in reducing
mortalities, severity of infection, enhancement of liver and kidney functions up to almost
normal values and improving quail immunity. Probiotics resulted in improvement of the
haematological and biochemical parameters as well as total serum proteins and serum
globulins. Dual administration of the lactobacilli and saccharomyces justified their synergistic
probiotics effect against quail chick pseudomoniasis.