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273778

Epidermal growth factor polymorphism (rs4444903) predicts hepatocellular carcinoma in Egyptian population

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Last updated: 22 Jan 2023

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Abstract

Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy in the world, with an increasing worldwide prevalence. Hepatocellular carcinoma (HCC) is the fifth most common cancer and thethird leading cause of cancer related mortality worldwide.  Epidermal growth factor (EGF) and its receptor play critical roles in carcinogenesis. A functional polymorphism in the EGF gene has been linked to increased cancer susceptibility. This study was aimed to investigate the association between both the EGF +61A/G polymorphism & its serum level and the risk for hepatocellular carcinoma (HCC) in Egyptian patients. Methods: We analyzed 140 (HCC) & 100 chronic hepatitis patients without any focal lesion. In addition to 110 subjects as a control group. All were subjected to PCR and genotyping of EGF +61A/G polymorphism was assessed by PCR-restriction fragment length polymorphism. Results: We found a significant difference between patients with HCC and those with chronic hepatitis versus controls in terms of the G allele. Conclusion: EGF +61GG genotype might be correlated with development of HCC as a risk factor in Egyptian patients with chronic liver disease.

DOI

10.21608/rjab.2019.273778

Keywords

carcinoma, hepatocellular, HCC, Polymorphisms, rs4444903

Authors

First Name

Rasha

Last Name

Fathy

MiddleName

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Affiliation

Molecular Biology Dept., Genetic Engineering & Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Egypt

Email

rasha.fathy@gebri.usc.edu.eg

City

-

Orcid

-

First Name

Shaden

Last Name

Muawia

MiddleName

-

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt

Email

shadenmuawia@yahoo.com

City

-

Orcid

-

First Name

Moustafa

Last Name

Sakr

MiddleName

-

Affiliation

professor of molecular genetics and molecular diagnosis, Molecular Diagnostics and Therapeutics Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt

Email

mostafa.sakr@gebri.usc.edu.eg

City

Sadat City

Orcid

-

First Name

Mohamed

Last Name

Elshal

MiddleName

-

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt

Email

mohamed.elshal@gebri.usc.edu.eg

City

-

Orcid

-

Volume

5

Article Issue

2

Related Issue

31330

Issue Date

2019-12-01

Receive Date

2019-11-05

Publish Date

2019-12-31

Page Start

32

Page End

40

Print ISSN

2356-9433

Online ISSN

2682-3470

Article File

RJAB_Volume 5_Issue 2_Pages 32-40.pdf

PDF . 300.1kB

Link

https://rjab.journals.ekb.eg/article_273778.html

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https://rjab.journals.ekb.eg/service?article_code=273778

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3

Type

Original Article

Type Code

890

Publication Type

Journal

Publication Title

Research Journal of Applied Biotechnology

Publication Link

https://rjab.journals.ekb.eg/

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Article

Created At

22 Jan 2023