Thiosemicarbazones and their metal complexes are very promising compounds which present awide range of pharmacological applications as antimicrobial, antiparasital, and antiviral agents In many circumstances the pharmacological activity of thiosemicarbazones increases upon coordination to metal ions. A new novel copper complex of thiosemicarbazide ligand has been prepared and
characterized by different physical and chemical methods such as 1H NMR Spectroscopy, IR
spectra, elemental analysis, molar conductance, electronic spectra and magnetic susceptibilities
measurements. Copper complex behaves as a neutral tridentate in nature , coordination takes
place via carbonyl oxygen , N(2)H and C=S respectively .Also the study of the effect of gamma
irradiation on ligand andCu(I) complex using different measurments devices. On the other side, the
antibacterial activity of ligand and Cu(I) complex against gram positive (Streptococcus pyogenes) and
gram negative( Escherichia coli) bacteria was investigated. The result revealed that Cu( I) complex
after gamma irradiation showed a higher antibacterial activity against gram positive (Streptococcus
pyogenes) and gram negative(Escherichia coli) bacteria than the ligand