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76807

Association of C4125A Polymorphisms of MDR-1 gene with childhood acute lymphoblastic leukaemia in Egyptian

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Last updated: 22 Jan 2023

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Abstract

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, though the etiology of the leukemia is poorly understood, both genetic and environmental factors appear to be involved. To investigate the possible role of MDR-1 (C4125A) polymorphism as risk factor for the development of ALL in this study on Egyptian children and to evaluate its prognostic role. Typing of MDR-1 (C4125A) polymorphism was done using RFLP-PCR for 120 patients with ALL and 100 healthy controls. The C allele (100%) and CC genotype (100%) were insignificant in both groups. Also, no relation between clinical data and C4125A genotypes. Thus, MDR-1 (C4125A) SNP may be not risk factor for the development of pediatric ALL in Egyptian patients.

DOI

10.21608/rjab.2019.76807

Keywords

ALL, MDR-1, Polymorphism, Egyptian

Authors

First Name

Roba

Last Name

Talaat

MiddleName

M.

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Sadat City, Egypt.

Email

roba.talaat@gebri.usc.edu.eg

City

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Orcid

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First Name

Medhat

Last Name

El-Kelliny

MiddleName

Y.K.

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Email

-

City

-

Orcid

-

First Name

Basima

Last Name

El-Akhras

MiddleName

A.

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Email

-

City

-

Orcid

-

First Name

Rania

Last Name

Bakry

MiddleName

M.

Affiliation

South Egypt Cancer Institute, Assiute University, Egypt.

Email

-

City

-

Orcid

-

First Name

Khaled

Last Name

Riad

MiddleName

F.

Affiliation

South Egypt Cancer Institute, Assiute University, Egypt.

Email

-

City

-

Orcid

-

First Name

Adel

Last Name

Guirgis

MiddleName

A.

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Email

-

City

-

Orcid

-

Volume

5

Article Issue

1

Related Issue

11477

Issue Date

2019-06-01

Receive Date

2020-03-10

Publish Date

2019-06-01

Page Start

80

Page End

89

Print ISSN

2356-9433

Online ISSN

2682-3470

Article File

RJAB_Volume 5_Issue 1_Pages 80-89.pdf

PDF . 928.1kB

Link

https://rjab.journals.ekb.eg/article_76807.html

Detail API

https://rjab.journals.ekb.eg/service?article_code=76807

Order

8

Type

Original Article

Type Code

890

Publication Type

Journal

Publication Title

Research Journal of Applied Biotechnology

Publication Link

https://rjab.journals.ekb.eg/

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Article

Created At

22 Jan 2023