Nonalcoholic fatty liver disease (NAFLD) is a major health problem and is considered as the most common worldwide liver disease. High fat diet (HFD) leads to NAFLD through the dysregulation of genes involved in lipid metabolism. Pomegranate Peel Extract (PPE) has many biological activities and could modify the risk of hyperlipidemia. This study was performed to investigate whether and how the pomegranate peel extract has a hepatosteatotic effect in NAFLD rats, and its role in the modulation of sterol regulatory element binding protein-1C (SREBP-1C) and sterol regulatory element binding protein-2 (SREBP-2) as a molecular target for this therapeutic effects in the NAFLD rats. Fifty male albino Wistar rats will be used in the present study, The NAFLD was induced in rats using HFD. Treatment the NAFLD rats with PPE at a dose dependent manner was significantly ameliorate hyperlipidemia, liver profile, correct glycemic index, IR-HOMA  and normalize the hepatic expression of SREBP-1C and SREBP-2. From the present study we can concluded that the PPE have efficient therapeutic effect against NAFLD through the modulation of SREBP-1C and SREBP-2.