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59641

THE ROLE OF BCL-2 ONCOPROTEIN IN HEPATITIS C-RELATED HEPATOCELLULAR CARCINOMA

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Last updated: 22 Jan 2023

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Abstract

Viral hepatitis has emerged as a major public health problem worldwide. There is increasing evidence that, several viral oncogenes such as core protein C virus (HCV) is playing a direct role in neoplastic transformation. The tumor development requires both increased proliferation and inhibition of apoptosis. There is increasing experimental evidence to suggest that bcl-2 plays a critical role in blocking apoptosis in cancer cells. In the present study we tried to explore the role of bcl-2 in development of viral hepatitis into hepatocellular carcinoma (HCC). Out of 105 participants; 50 patients were HCV positive infected patients, 30 HCC patients either infected with HCV (HCC/HCV) or not (HCC) and 25 healthy volunteers were also included. We determined the serum level of bcl-2, AFP and HCV-RNA viral load in patients and compared them with the other clinicopathological parameters. Increased serum bcl-2 level was showed in HCC/HCV infected patients more than HCV and controls (P=0.001) and more than HCC patients (P=0.018). A significant positive correlation between AFP and total load of viremia was elucidated (r=0.345, P=0.014) in the HCV infected patients who didn′t develop HCC. By analyzing the diagnostic performance of the studied parameters among the different groups. Bcl-2 was found to be a significant prognostic marker for the progression of HCC, as it represented two or more diagnostic values (Sensitivity 80 % , 70% and specificity 60%, 70% respectively).and (OR=6.0, 95% CI=1.74-20.59& OR=5.4 & 95% CI=1.75-16.88).These results make bcl-2 a candidate marker for HCC progression following HCV infection in Egyptian patients.


DOI

10.21608/rjab.2016.59641

Keywords

Hepatocellular carcinoma (HCC) hepatitis C virus (HCV), Bcl-2

Authors

First Name

Gehan,

Last Name

Ibrahim

MiddleName

M.

Affiliation

Molecular biology Dept., Genetic engineering and biotechnology research institute University of Sadat City, Egypt.

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First Name

Shaden

Last Name

Muawia

MiddleName

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Affiliation

Molecular biology Dept., Genetic engineering and biotechnology research institute University of Sadat City, Egypt.

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First Name

Mohamed

Last Name

El-Shahat

MiddleName

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Affiliation

Molecular biology Dept., Genetic engineering and biotechnology research institute University of Sadat City, Egypt.

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First Name

Tarek

Last Name

Kamel

MiddleName

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Affiliation

Molecular biology Dept., Genetic engineering and biotechnology research institute University of Sadat City, Egypt.

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Volume

2

Article Issue

Special issue (1) for the first International Conference of Genetic Engineering and Biotechnology

Related Issue

9011

Issue Date

2016-11-01

Receive Date

2019-11-17

Publish Date

2016-11-01

Page Start

101

Page End

110

Print ISSN

2356-9433

Online ISSN

2682-3470

Link

https://rjab.journals.ekb.eg/article_59641.html

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https://rjab.journals.ekb.eg/service?article_code=59641

Order

11

Type

Original Article

Type Code

890

Publication Type

Journal

Publication Title

Research Journal of Applied Biotechnology

Publication Link

https://rjab.journals.ekb.eg/

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Article

Created At

22 Jan 2023