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57521

Detection of oxidative stress induced by ciprofloxacin in imatuer rat

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Last updated: 04 Jan 2025

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Abstract

Fluoroquinolones are a group of antibiotics broadly used because of their wide spectrum activity against both Gram-negative and Gram positive bacteria. It is well tolerated in patients but their uses have been associated with numerous adverse effects, including adverse central nervous system (CNS) effects and juvenile joint toxicity due to oxidative stress.       This study designed to detect the oxidative stress caused by administration of ciprofloxacin alone and in concert with glutathione. Ciprofloxacin (400 mg/kg body weight) administered to rats alone or with glutathione (100 mg/kg) body weight for7 days injection via intra peritoneal route  to detect effects on glutathione peroxidase and glutathione reductase as oxidative stress enzymes markers. The data obtained demonstrated presence of the two enzymes which supplies further evidence that fluoroquinolones at therapeutic doses promote oxidative stress and the crucial role of glutathione in ptotection against ciprofloxacin side effects on bone.

DOI

10.21608/rjab.2018.57521

Keywords

ciprofloxacin, Oxidative Stress, side effects, antioxidants

Authors

First Name

Amal

Last Name

AbdEl-Aziz

MiddleName

A.

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

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Orcid

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First Name

Yahya

Last Name

Naguib

MiddleName

-

Affiliation

Clinical Physiology Department, Faculty of Medicine, Menofiya University, Menofiyam Egypt

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Orcid

-

First Name

Wafaa

Last Name

Zahran

MiddleName

A.

Affiliation

Microbiology and immunology Department, faculty of medicine, Menofiya University, Menofiya, Egypt

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Orcid

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First Name

Hoda

Last Name

Mahrous

MiddleName

-

Affiliation

Industerial Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

Email

hmahrous7@yahoo.com

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-

Orcid

-

First Name

Hany

Last Name

Khalil

MiddleName

-

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

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Orcid

-

First Name

Saadiya

Last Name

El-Nahas

MiddleName

A.

Affiliation

1Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

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Volume

4

Article Issue

1

Related Issue

8741

Issue Date

2018-06-01

Receive Date

2019-11-07

Publish Date

2018-06-01

Page Start

77

Page End

81

Print ISSN

2356-9433

Online ISSN

2682-3470

Article File

RJAB_Volume 4_Issue 1_Pages 77-81.pdf

PDF . 624.8kB

Link

https://rjab.journals.ekb.eg/article_57521.html

Detail API

https://rjab.journals.ekb.eg/service?article_code=57521

Order

6

Type

Original Article

Type Code

890

Publication Type

Journal

Publication Title

Research Journal of Applied Biotechnology

Publication Link

https://rjab.journals.ekb.eg/

MainTitle

Detection of oxidative stress induced by ciprofloxacin in imatuer rat

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Article

Created At

22 Jan 2023